Evidence map›Paper›PMID 29800811›Full record

ArticleThe Journal of nutritional biochemistry2018

Synbiotics Bifidobacterium infantis and milk oligosaccharides are effective in reversing cancer-prone nonalcoholic steatohepatitis using western diet-fed FXR knockout mouse models.

Prasant Kumar Jena, Lili Sheng, Nidhi Nagar, Chao Wu, Daniela Barile, David A Mills, Yui-Jui Yvonne Wan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of nutritional biochemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Prasant Kumar JenaDepartment of Pathology and Laboratory Medicine, University of California, Davis, Sacramento 95817, CA, USA.
Lili ShengDepartment of Pathology and Laboratory Medicine, University of California, Davis, Sacramento 95817, CA, USA.
Nidhi NagarDepartment of Pathology and Laboratory Medicine, University of California, Davis, Sacramento 95817, CA, USA.
Chao WuResearch and Development, Hilmar Ingredients, Hilmar 95324, CA, USA.
Daniela BarileDepartment of Food Science and Technology, University of California, Davis 95616, CA, USA.
David A MillsDepartment of Food Science and Technology, University of California, Davis 95616, CA, USA; Department of Viticulture and Enology, University of California, Davis 95616, CA, USA.
Yui-Jui Yvonne WanDepartment of Pathology and Laboratory Medicine, University of California, Davis, Sacramento 95817, CA, USA. Electronic address: yjywan@ucdavis.edu.
University of California, Davis · US

Funding

The Role of Probiotic Bifidobacteria and Bile Acid Metabolism in CarcinogenesisU01CA179582 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MILLS, DAVID ANDREW, SLUPSKY, CAROLYN · 2014 to 2018
$2.8M
Liver Cancer Therapy by MiR-22 and Its InducersR01CA222490 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI WAN, YU-JUI YVONNE · 2018 to 2023
$2.1M
NCI NIH HHS R01 CA222490NCI NIH HHS U01 CA179582
6 · The paper itself

Abstract

Milk oligosaccharides (MO) selectively increase the growth of Bifidobacterium infantis (B. infantis). This study examines the effects of bovine MO and B. infantis in preventing nonalcoholic steatohepatitis (NASH) in Western diet (WD)-fed bile acid (BA) receptor FXR (farnesoid x receptor) knockout (KO) mice. WD-fed FXR KO mice have cancer-prone NASH and reduced B. infantis. MO and/or B. infantis supplementation improved their insulin sensitivity and reduced hepatic inflammation. Additionally, B. infantis, but not MO, decreased hepatic triglyceride and cholesterol. A combination of both further reduced hepatic cholesterol, the precursor of BAs. All three treatments modulated serum and hepatic BA profile. Moreover, B. infantis and MO decreased hepatic CYP7A1 and induced Sult2a1, Sult2a2, and Sult2a3 suggesting reduced BA synthesis and increased detoxification. Furthermore, B. infantis and MO increased ileal BA membrane receptor TGR5-regulated signaling. Together, via BA-regulated signaling, synbiotics B. infantis and MO have their unique and combined effects in reversing NASH.

Indexed as

Bifidobacterium longum subspecies infantisSynbioticsAnimalsBile Acids and SaltsDiet, WesternDisease Models, AnimalFemaleMaleMice, Inbred C57BLMice, KnockoutMilkNon-alcoholic Fatty Liver DiseaseOligosaccharidesReceptor, Farnesoid X-ActivatedReceptors, Cytoplasmic and NuclearReceptors, G-Protein-CoupledBile Acids and SaltsGpbar1 protein, mouseOligosaccharidesReceptor, Farnesoid X-ActivatedReceptors, Cytoplasmic and NuclearReceptors, G-Protein-CoupledBile acidDysbiosisLiver cancerMicrobiotaPrebioticsProbioticsTGR5

Identifiers

PMID29800811
PMCPMC6015547
OpenAlexW2802792185

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.