Evidence map›Paper›PMID 29800768›Full record

ArticleEnvironment international2018

Short-term effects of airport-associated ultrafine particle exposure on lung function and inflammation in adults with asthma.

Rima Habre, Hui Zhou, Sandrah P Eckel, Temuulen Enebish, Scott Fruin, Theresa Bastain, Edward Rappaport, Frank Gilliland

Open access · greenAbstract read
In one paragraph

Article in Environment international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 2 pooled it
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 121 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Rima HabreDivision of Environmental Health, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. Electronic address: habre@usc.edu.
Hui ZhouDivision of Environmental Health, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Sandrah P EckelDivision of Biostatistics, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Temuulen EnebishDivision of Environmental Health, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Scott FruinDivision of Environmental Health, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Theresa BastainDivision of Environmental Health, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Edward RappaportDivision of Environmental Health, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Frank GillilandDivision of Environmental Health, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
University of Southern California · US

Funding

Translational Research Support CoreP30ES007048 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ROB S MCCONNELL · 1996 to 2026
$46.4M
Early detection of adverse respiratory effects from air pollutionR01ES023262 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BERHANE, KIROS T, GILLILAND, FRANK D. · 2013 to 2016
$2.0M
Statistical methods for exhaled breath biomarkers in environmental epidemiologyR01ES027860 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ECKEL, SANDRAH PROCTOR · 2017 to 2019
$1.1M
Methods for modeling air pollution effects on exhaled biomarkersK22ES022987 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ECKEL, SANDRAH PROCTOR · 2013 to 2015
$478k
NIEHS NIH HHS K22 ES022987NIEHS NIH HHS P30 ES007048NIEHS NIH HHS R01 ES023262NIEHS NIH HHS R01 ES027860
6 · The paper itself

Abstract

backgroundExposure to ultrafine particles (UFP, particles with aerodynamic diameter < 100 nm) is associated with reduced lung function and airway inflammation in individuals with asthma. Recently, elevated UFP number concentrations (PN) from aircraft landing and takeoff activity were identified downwind of the Los Angeles International Airport (LAX) but little is known about the health impacts of airport-related UFP exposure.

methodsWe conducted a randomized crossover study of 22 non-smoking adults with mild to moderate asthma in Nov-Dec 2014 and May-Jul 2015 to investigate short-term effects of exposure to LAX airport-related UFPs. Participants conducted scripted, mild walking activity on two occasions in public parks inside (exposure) and outside (control) of the high UFP zone. Spirometry, multiple flow exhaled nitric oxide, and circulating inflammatory cytokines were measured before and after exposure. Personal UFP PN and lung deposited surface area (LDSA) and stationary UFP PN, black carbon (BC), particle-bound PAHs (PB-PAH), ozone (O

resultsA high two-hour walking period average contrast of ~34,000 particles·cm

conclusionsTo our knowledge, our study is the first to demonstrate increased acute systemic inflammation following exposure to airport-related UFPs. Health effects associated with roadway traffic exposure were distinct. This study emphasizes the importance of multi-pollutant measurements and modeling techniques to disentangle sources of UFPs contributing to the complex urban air pollution mixture and to evaluate population health risks.

Indexed as

AirportsAsthmaInhalation ExposurePneumoniaAdultAir PollutantsCross-Over StudiesHumansInterleukin-6Particulate MatterRandom AllocationAir PollutantsInterleukin-6Particulate Matter

Identifiers

PMID29800768
PMCPMC6368339
OpenAlexW2803538383

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.