ArticleBone2018
Relative contributions of lean and fat mass to bone strength in young Hispanic and non-Hispanic girls.
Article in Bone, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Association between Body Composition and Bone Mineral Density in Children and Adolescents: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2021Pooled it
- Association Between Muscular Strength and Bone Health from Children to Young Adults: A Systematic Review and Meta-analysis.Sports medicine (Auckland, N.Z.) · 2020Pooled it
- Lean mass development trajectories in children and adolescents and their associations with musculoskeletal health in emerging adulthood.Frontiers in endocrinology · 2026Article
- Muscle Mass as a Biomarker for Health Status and Function in Pediatric Individuals with Neuromuscular Disabilities: A Systematic Review.Children (Basel, Switzerland) · 2024Review
- Predictive factors of bone strength variation in adolescent girls according to body composition.Annals of pediatric endocrinology & metabolism · 2024Article
- Risk of wrist fracture, estimated by the load-to-strength ratio, declines following sleeve gastrectomy in adolescents and young adults.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024Article
- Peak Bone Mass Formation: Modern View of the Problem.Biomedicines · 2023Review
- Accurate Machine Learning Model to Diagnose Chronic Autoimmune Diseases Utilizing Information From B Cells and Monocytes.Frontiers in immunology · 2022Article
- Bone parameters of elite athletes with oligomenorrhea and prevalence seeking medical attention: a cross-sectional study.Journal of bone and mineral metabolism · 2021Article
- Association of Body Compositions and Bone Mineral Density in Chinese Children and Adolescents: Compositional Data Analysis.BioMed research international · 2021Article
- [Fractures and bone mineral density in childhood].Zeitschrift fur Rheumatologie · 2019Review
- Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
backgroundWith the high prevalence of childhood obesity, especially among Hispanic children, understanding how body weight and its components of lean and fat mass affect bone development is important, given that the amount of bone mineral accrued during childhood can determine osteoporosis risk later in life. The aim of this study was to assess the independent contributions of lean and fat mass on volumetric bone mineral density (vBMD), geometry, and strength in both weight-bearing and non-weight-bearing bones of Hispanic and non-Hispanic girls.
methodsBone vBMD, geometry, and strength were assessed at the 20% distal femur, the 4% and 66% distal tibia, and the 66% distal radius of the non-dominant limb of 326, 9- to 12-year-old girls using peripheral quantitative computed tomography (pQCT). Total body lean and fat mass were measured by dual-energy x-ray absorptiometry (DXA). Multiple linear regression was used to assess the independent relationships of fat and lean mass with pQCT bone measures while adjusting for relevant confounders. Potential interactions between ethnicity and both fat and lean mass were also tested.
resultsLean mass was a significant positive contributor to all bone outcomes (p < 0.05) with the exception of vBMD at diaphyseal sites. Fat mass was a significant contributor to bone strength at weight bearing sites, but did not significantly contribute to bone strength at the non-weight bearing radius and was negatively associated with radius cortical content and thickness. Bone measures did not significantly differ between Hispanic and non-Hispanic girls, although there was a significant interaction between ethnicity and fat mass with total bone area at the femur (p = 0.02) and 66% tibia (p = 0.005) as well as bone strength at the femur (p = 0.03).
conclusionLean mass is the main determinant of bone strength for appendicular skeletal sites. Fat mass contributes to bone strength in the weight-bearing skeleton but does not add to bone strength in non-weight-bearing locations and may potentially be detrimental. Bone vBMD, geometry, and strength did not differ between Hispanic and non-Hispanic girls; fat mass may be a stronger contributor to bone strength in weight-bearing bones of Hispanic girls compared to non-Hispanic.
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Registered trials
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