ArticleOsteoarthritis and cartilage2018
Alterations in quadriceps muscle cellular and molecular properties in adults with moderate knee osteoarthritis.
Article in Osteoarthritis and cartilage, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07471204 (Muscle Oxygenation and Recovery Dynamics in Individuals With Knee Osteoarthritis), which is not on this map. Cited by 53 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Muscle Oxygenation and Recovery Dynamics in Individuals With Knee Osteoarthritis: A Case-Control Study
Who cites it
53 citing papers in PubMed, 2 syntheses or guidelines pooled it, 87 citations in OpenAlex.
- Disease severity affects knee range of motion but not strength deficits in knee osteoarthritis: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- The use of tensiomyography in older adults: a systematic review.Frontiers in physiology · 2023Pooled it
- Electroacupuncture with extensor exercise improves the contraction elastic density of quadriceps in short and long term for knee osteoarthritis.Clinical rheumatology · 2025Trial
- The Efficacy of Acupuncture, Exercise Rehabilitation, and Their Combination in the Treatment of Knee Osteoarthritis: A Randomized Controlled Trial.Journal of pain research · 2024Trial
- Perioperative assessment of muscle inflammation susceptibility in patients with end-stage osteoarthritis.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Trial
- Decreased Thigh Muscle Cross-Sectional Area Following Anterior Cruciate Ligament Injury Depends on Concomitant Meniscal Injury and Subject Sex.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026Article
- Pathological mechanisms of osteoarthritis in the network of geriatric comorbidities: Emerging insights from organs-crosstalk.Journal of orthopaedic translation · 2026Review
- From paradox to population impact: Rethinking strengthening in knee osteoarthritis - A state-of-the-art review.Osteoarthritis and cartilage open · 2026Review
- Reliability of quadriceps and hamstring muscle stiffness measured by ultrasound shear wave elastography in patients with knee osteoarthritis.BMC musculoskeletal disorders · 2026Article
- Beyond Histology: Tensiomyography as an Integrated Measure of Muscle Function in Osteoporotic and Osteoarthritic Patients.Journal of clinical medicine · 2026Article
- Tensiomyography-derived contractile parameters in sarcopenic and non-sarcopenic older adults.Frontiers in aging · 2026Article
- Distribution of lower limb muscles may be associated with the progression of knee osteoarthritis and sarcopenia: a cross-sectional study.Frontiers in medicine · 2026Article
- MRI-based radiomics to determine the role of thigh muscle quality in the development of knee osteoarthritis: A discovery and validation study.Journal of advanced research · 2026Article
- Assessment of vastus medialis muscle quality in knee osteoarthritis using ultrashort echo time magnetization transfer MR imaging.Skeletal radiology · 2025Article
- Fork in the road: therapeutic and pathological actions for fibro-adipogenic progenitors following musculoskeletal injury.The Journal of physiology · 2025Review
- Knee Health Is a Major Determinant of Mobility Across the Healthspan.Journal of functional morphology and kinesiology · 2025Review
- The articularis genu as a surrogate for structural determinants of peri-articular myopenia in osteoarthritis.Scientific reports · 2025Article
- Factors, characteristics and influences of the changes of muscle activation patterns for patients with knee osteoarthritis: a review.Journal of orthopaedic surgery and research · 2025Review
- Alterations in whole muscle quality and physiological cross-sectional area measured with quantitative MRI following ACL injury.Journal of translational medicine · 2025Article
- Phase Angle as a Predictor of Walking Independence in Patients Undergoing Stroke Rehabilitation: A Preliminary Study.Physical therapy research · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveQuadriceps muscle weakness is common in knee osteoarthritis (OA). While pain, disuse, and atrophy are commonly cited causes for muscle weakness in OA, emerging evidence suggests changes in muscle quality also occur. Alterations in muscle quality are not well understood, but likely include both cellular and morphologic adaptions. The purpose of this study was to conduct the first cellular-level analysis of the vastus lateralis in adults with moderate knee OA.
methodsVastus lateralis biopsies were obtained from 24 subjects with moderate knee OA and 15 healthy controls. Quadriceps strength, muscle fiber cross sectional area (CSA), fiber type distribution, extracellular matrix (ECM) content, satellite cell abundance, and profibrotic gene expression were assessed.
resultsRelative to controls, quadriceps strength was significantly lower in OA subjects (OA 62.23, 50.67-73.8 Nm vs 91.46, 75.91-107.0 Nm, P = 0.003) despite no difference in fiber CSA. OA subjects had significantly fewer Type I fibers (OA 41.51, 35.56-47.47% vs 53.07, 44.86-61.29%, P = 0.022) and more hybrid IIa/x fibers (OA 24.61, 20.61-28.61% vs 16.4, 11.60-21.20%, P = 0.009). Significantly greater ECM content, lower satellite cell density, and higher profibrotic gene expression was observed with OA, and muscle collagen content was inversely correlated to strength and satellite cell (SC) density.
conclusionLower quadriceps function with moderate OA may not result from fiber size impairments, but is associated with ECM expansion. Impaired satellite cell density, high profibrotic gene expression, and a slow-to-fast fiber type transition may contribute to reduced muscle quality in OA. These findings can help guide therapeutic interventions to enhance muscle function with OA.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.