ReviewNeurosurgery2019
Toward Functional Restoration of the Central Nervous System: A Review of Translational Neuroscience Principles.
Review in Neurosurgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- The impact of non-invasive brain-computer interface technology on the therapeutic effect of patients with spinal cord injury: a summary of evidence based on meta-analysis.Journal of neuroengineering and rehabilitation · 2025Pooled it
- Changes in Somatomotor Network Connectivity Differentiate Better Versus Worse Recovery of Hand Dexterity After Brain Tumor Surgery: A Cohort Study.Neural plasticity · 2026Article
- Emerging trends in cell-based therapies: contemporary advances and ethical considerations in translational neurosurgical oncology.Journal of neuro-oncology · 2025Review
- Revolutionizing neural regeneration with smart responsive materials: Current insights and future prospects.Bioactive materials · 2025Review
- Advances in 3D printing combined with tissue engineering for nerve regeneration and repair.Journal of nanobiotechnology · 2025Review
- Theoretical and Practical Neuroscience Tools for Neurosurgery.Advances and technical standards in neurosurgery · 2025Review
- Axon-like aligned conductive CNT/GelMA hydrogel fibers combined with electrical stimulation for spinal cord injury recovery.Bioactive materials · 2024Article
- Understanding the pathophysiology of acute critical illness: translational lessons from zebrafish models.Intensive care medicine experimental · 2024Review
- Exploring core and bridge symptoms in patients recovering from stroke: a network analysis.Frontiers in neurology · 2024Article
- Quantifying Hand Strength and Isometric Pinch Individuation Using a Flexible Pressure Sensor Grid.Sensors (Basel, Switzerland) · 2023Article
- Quantitative assessments of finger individuation with an instrumented glove.Journal of neuroengineering and rehabilitation · 2023Article
- Large-scale brain networks and intra-axial tumor surgery: a narrative review of functional mapping techniques, critical needs, and scientific opportunities.Frontiers in human neuroscience · 2023Review
- Restoring After Central Nervous System Injuries: Neural Mechanisms and Translational Applications of Motor Recovery.Neuroscience bulletin · 2022Review
- Editorial: Neuroplasticity in Rehabilitation.Frontiers in rehabilitation sciences · 2022Article
- A Time-Course Study of the Expression Level of Synaptic Plasticity-Associated Genes in Un-Lesioned Spinal Cord and Brain Areas in a Rat Model of Spinal Cord Injury: A Bioinformatic Approach.International journal of molecular sciences · 2021Article
- Spinal cord stimulation and rehabilitation in an individual with chronic complete L1 paraplegia due to a conus medullaris injury: motor and functional outcomes at 18 months.Spinal cord series and cases · 2020Article
- From severity scoring to predictive analytics: the emerging role of AI in neurosurgery.Frontiers in neurologyReview
- Exploring relationships between abnormal within-network functional connectivity, preoperative brain tumor variables, and neuropsychological test scores.Neuro-oncology advancesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
Injury to the central nervous system (CNS) can leave patients with devastating neurological deficits that may permanently impair independence and diminish quality of life. Recent insights into how the CNS responds to injury and reacts to critically timed interventions are being translated into clinical applications that have the capacity to drastically improve outcomes for patients suffering from permanent neurological deficits due to spinal cord injury, stroke, or other CNS disorders. The translation of such knowledge into practical and impactful treatments involves the strategic collaboration between neurosurgeons, clinicians, therapists, scientists, and industry. Therefore, a common understanding of key neuroscientific principles is crucial. Conceptually, current approaches to CNS revitalization can be divided by scale into macroscopic (systems-circuitry) and microscopic (cellular-molecular). Here we review both emerging and well-established tenets that are being utilized to enhance CNS recovery on both levels, and we explore the role of neurosurgeons in developing therapies moving forward. Key principles include plasticity-driven functional recovery, cellular signaling mechanisms in axonal sprouting, critical timing for recovery after injury, and mechanisms of action underlying cellular replacement strategies. We then discuss integrative approaches aimed at synergizing interventions across scales, and we make recommendations for the basis of future clinical trial design. Ultimately, we argue that strategic modulation of microscopic cellular behavior within a macroscopic framework of functional circuitry re-establishment should provide the foundation for most neural restoration strategies, and the early involvement of neurosurgeons in the process will be crucial to successful clinical translation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.