ArticleSchizophrenia bulletin2019
Impaired Effective Connectivity During a Cerebellar-Mediated Sensorimotor Synchronization Task in Schizophrenia.
Article in Schizophrenia bulletin, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Functional neuroimaging in patients with catatonia: A systematic review.Journal of psychosomatic research · 2024Pooled it
- Schizophrenia and disordered sensorimotor control: challenges, mechanisms and opportunities.Brain : a journal of neurology · 2026Review
- Functional organization of the primary motor cortex in psychosis and the potential role of intereffector regions in psychomotor slowing.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Estimating brain effective connectivity from time series using recurrent neural networks.Physical and engineering sciences in medicine · 2025Article
- Bridging the gap between aberrant time processing and cognitive dysfunction in schizophrenia: a potential core feature?Schizophrenia (Heidelberg, Germany) · 2025Review
- Reduced finger tapping speed in patients with schizophrenia and psychomotor slowing: an exploratory fMRI study.Frontiers in psychiatry · 2025Article
- Psychomotor slowing in schizophrenia is associated with aberrant postural control.Schizophrenia (Heidelberg, Germany) · 2024Article
- Isolation of Distinct Networks Driving Action and Cognition in Psychomotor Processes.Biological psychiatry · 2024Article
- Insular and Striatal Correlates of Uncertain Risky Reward Pursuit in Schizophrenia.Schizophrenia bulletin · 2023Article
- Consider the pons: bridging the gap on sensory prediction abnormalities in schizophrenia.Trends in neurosciences · 2022Review
- Cerebellar Structure and Cognitive Ability in Psychosis.Biological psychiatry · 2022Article
- The positive dimension of schizotypy is associated with a reduced attenuation and precision of self-generated touch.Schizophrenia (Heidelberg, Germany) · 2022Article
- Abnormal synaptic plasticity and impaired cognition in schizophrenia.World journal of psychiatry · 2022Review
- Altered functional connectivity of cerebellar networks in first-episode schizophrenia.Frontiers in cellular neuroscience · 2022Article
- Intrinsic neural network dynamics in catatonia.Human brain mapping · 2021Article
- Why is there symptom coupling of psychological and motor changes in psychomotor mechanisms? Insights from the brain's topography.Molecular psychiatry · 2021Article
- Cerebellar Activation Deficits in Schizophrenia During an Eyeblink Conditioning Task.Schizophrenia bulletin open · 2021Article
- Weaker Cerebellocortical Connectivity Within Sensorimotor and Executive Networks in Schizophrenia Compared to Healthy Controls: Relationships with Processing Speed.Brain connectivity · 2020Article
- Compression of Cerebellar Functional Gradients in Schizophrenia.Schizophrenia bulletin · 2020Article
- Cerebellar-cortical dysconnectivity in resting-state associated with sensorimotor tasks in schizophrenia.Human brain mapping · 2020Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Prominent conceptual models characterize schizophrenia as a dysconnectivity syndrome, with recent research focusing on the contributions of the cerebellum in this framework. The present study examined the role of the cerebellum and its effective connectivity to the cerebrum during sensorimotor synchronization in schizophrenia. Specifically, the role of the cerebellum in temporally coordinating cerebral motor activity was examined through path analysis. Thirty-one individuals diagnosed with schizophrenia and 40 healthy controls completed a finger-tapping fMRI task including tone-paced synchronization and self-paced continuation tapping at a 500 ms intertap interval (ITI). Behavioral data revealed shorter and more variable ITIs during self-paced continuation, greater clock (vs motor) variance, and greater force of tapping in the schizophrenia group. In a whole-brain analysis, groups showed robust activation of the cerebellum during self-paced continuation but not during tone-paced synchronization. However, effective connectivity analysis revealed decreased connectivity in individuals with schizophrenia between the cerebellum and primary motor cortex but increased connectivity between cerebellum and thalamus during self-paced continuation compared with healthy controls. These findings in schizophrenia indicate diminished temporal coordination of cerebral motor activity by cerebellum during the continuation tapping portion of sensorimotor synchronization. Taken together with the behavioral finding of greater temporal variability in schizophrenia, these effective connectivity results are consistent with structural and temporal models of dysconnectivity in the disorder.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.