ArticleNucleic acids research2018
Redox-dependent control of i-Motif DNA structure using copper cations.
Article in Nucleic acids research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Cuprous Ions Binding to Cytosine and Guanine Oligonucleotides.Chembiochem : a European journal of chemical biology · 2026Article
- i-Motif, not G-quadruplex, stability regulates insulin expression.Nucleic acids research · 2026Article
- Are i-Motif Structures in DNA Compatible with Cytosine-Ag(I)-Cytosine Base Pairs?Angewandte Chemie (International ed. in English) · 2026Article
- Effects of flanking regions on DNA i-motif folding and stability.Nucleic acids research · 2025Article
- Porphyrins as Chiroptical Conformational Probes for Biomolecules.Molecules (Basel, Switzerland) · 2025Review
- Modulation of Nrf2 expression by targeting i-motif DNA.Communications chemistry · 2025Article
- Insights into the Molecular Structure, Stability, and Biological Significance of Non-Canonical DNA Forms, with a Focus on G-Quadruplexes and i-Motifs.Molecules (Basel, Switzerland) · 2024Review
- The roles of DNA methylation on pH dependent i-motif (iM) formation in rice.Nucleic acids research · 2024Article
- Intramolecular Folding of PolyT Oligonucleotides Induced by Cooperative Binding of Silver(I) Ions.Molecules (Basel, Switzerland) · 2022Article
- CpG Methylation Altered the Stability and Structure of the i-Motifs Located in the CpG Islands.International journal of molecular sciences · 2022Article
- A pH and MgACS omega · 2021Article
- AC-motif: a DNA motif containing adenine and cytosine repeat plays a role in gene regulation.Nucleic acids research · 2021Article
- Mechanical unfolding of ensemble biomolecular structures by shear force.Chemical science · 2021Article
- Opposite Effects of Potassium Ions on the Thermal Stability of i-Motif DNA in Different Buffer Systems.ACS omega · 2021Article
- Ferrocene-Containing DNA Monolayers: Influence of Electrostatics on the Electron Transfer Dynamics.Langmuir : the ACS journal of surfaces and colloids · 2021Article
- Structures and stability of simple DNA repeats from bacteria.The Biochemical journal · 2020Review
- Epigenetic modification of cytosines fine tunes the stability of i-motif DNA.Nucleic acids research · 2020Article
- Heteroleptic Coordination Environments in Metal-Mediated DNA G-Quadruplexes.Frontiers in chemistry · 2020Article
- Tricky Topology: Persistence of Folded Human Telomeric i-Motif DNA at Ambient Temperature and Neutral pH.Frontiers in chemistry · 2020Article
- Tailored Transition-Metal Coordination Environments in Imidazole-Modified DNA G-Quadruplexes.Chemistry (Weinheim an der Bergstrasse, Germany) · 2019Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous computational studies have shown that Cu+ can act as a substitute for H+ to support formation of cytosine (C) dimers with similar conformation to the hemi-protonated base pair found in i-motif DNA. Through a range of biophysical methods, we provide experimental evidence to support the hypothesis that Cu+ can mediate C-C base pairing in i-motif DNA and preserve i-motif structure. These effects can be reversed using a metal chelator, or exposure to ambient oxygen in the air that drives oxidation of Cu+ to Cu2+, a comparatively weak ligand. Herein, we present a dynamic and redox-sensitive system for conformational control of an i-motif forming DNA sequence in response to copper cations.
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