Evidence map›Paper›PMID 29800080›Full record

Trial reportAnnals of behavioral medicine : a publication of the Society of Behavioral Medicine2019

Early Weight Loss in Behavioral Treatment Predicts Later Rate of Weight Loss and Response to Pharmacotherapy.

Jena Shaw Tronieri, Thomas A Wadden, Ariana M Chao, Rebecca L Pearl, Naji Alamuddin, Robert I Berkowitz

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Annals of behavioral medicine : a publication of the Society of Behavioral Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jena Shaw TronieriCenter for Weight and Eating Disorders, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Suite, Philadelphia, PA, USA.
Thomas A WaddenCenter for Weight and Eating Disorders, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Suite, Philadelphia, PA, USA.
Ariana M ChaoCenter for Weight and Eating Disorders, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Suite, Philadelphia, PA, USA.
Rebecca L PearlCenter for Weight and Eating Disorders, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Suite, Philadelphia, PA, USA.
Naji AlamuddinCenter for Weight and Eating Disorders, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Suite, Philadelphia, PA, USA.
Robert I BerkowitzCenter for Weight and Eating Disorders, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Suite, Philadelphia, PA, USA.
University of Pennsylvania · USChildren's Hospital of Philadelphia · US

Funding

RESEARCH ON VULNERABLE WOMEN CHILDREN AND FAMILIEST32NR007100 · NINR · UNIVERSITY OF PENNSYLVANIA · PI MEDOFF-COOPER, BARBARA S · 1998 to 2018
$7.2M
Reducing Weight Stigma to Improve Long-Term Weight LossK23HL140176 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI PEARL, REBECCA L · 2018 to 2022
$835k
NHLBI NIH HHS K23 HL140176NINR NIH HHS T32 NR007100
6 · The paper itself

Abstract

backgroundEarly weight loss (EWL) in the first 1-2 months of behavioral treatment is a strong predictor of later total weight loss. It is not clear whether participants with lower early losses lose less in ongoing treatment or simply fail to overcome the smaller initial loss. Furthermore, no study has tested whether EWL in behavioral treatment predicts response to a different treatment modality, such as pharmacotherapy.

methodsData were from 170 participants with obesity (baseline BMI = 40.8 ± 5.8 kg/m2, 87.6% female; 71.3% Black) enrolled in a two-phase trial. Data from the weight loss phase, which provided weekly lifestyle counseling and a meal replacement diet, were used to examine the relationship between 4-week EWL and subsequent rate of weight loss in behavioral treatment. Data from the maintenance phase, in which 137 participants who had lost ≥5% of initial weight were randomized to 52 weeks of maintenance counseling with lorcaserin or placebo, were used to determine whether EWL with behavioral treatment affects the benefit of pharmacotherapy.

resultsEWL in the first 4 weeks of behavioral treatment (3.6 ± 1.7%) predicted greater total losses at Week 14 (r2 = 0.61, p < .001) and a faster rate of weight loss in the subsequent 9 weeks of the program (p < .001). During the maintenance phase, lower EWL in behavioral treatment predicted a greater benefit of lorcaserin, in comparison with placebo, for the maintenance of a ≥5% loss at Weeks 24 and 52.

conclusionsThese findings support recommendations to modify treatment for individuals with low EWL.

Indexed as

Behavior TherapyLife StyleWeight LossAdultAnti-Obesity AgentsBenzazepinesFemaleHumansMaleMiddle AgedObesityPrognosisTreatment OutcomeAnti-Obesity AgentsBenzazepineslorcaserinAnti-obesity agentsBehavior therapyEarly weight lossObesityWeight loss predictors

Identifiers

PMID29800080
PMCPMC6374712
OpenAlexW2804927097

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.