ArticlePloS one2018
Transient viscous response of the human cornea probed with the Surface Force Apparatus.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- The effect of corneal crosslinking on the rigidity of the cornea estimated using a modified algorithm for the Schiøtz tonometer.Indian journal of ophthalmology · 2021Trial
- Preoperative Corneal Astigmatic Direction is Associated with Stromal Mechanical Anisotropy in SMILE-Derived Lenticules.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- Ocular bio-lubricating materials: from lubrication mechanism to dry eye syndrome treatment.Regenerative biomaterials · 2025Review
- Pathological cardiolipin-promoted membrane hemifusion stiffens pulmonary surfactant membranes.Biophysical journal · 2022Article
- A clinical method for estimating the modulus of elasticity of the human cornea in vivo.PloS one · 2020Article
- Influence of polydimethylsiloxane substrate stiffness on corneal epithelial cells.Royal Society open science · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
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Abstract
Knowledge of the biomechanical properties of the human cornea is crucial for understanding the development of corneal diseases and impact of surgical treatments (e.g., corneal laser surgery, corneal cross-linking). Using a Surface Force Apparatus we investigated the transient viscous response of the anterior cornea from donor human eyes compressed between macroscopic crossed cylinders. Corneal biomechanics was analyzed using linear viscoelastic theory and interpreted in the framework of a biphasic model of soft hydrated porous tissues, including a significant contribution from the pressurization and viscous flow of fluid within the corneal tissue. Time-resolved measurements of tissue deformation and careful determination of the relaxation time provided an elastic modulus in the range between 0.17 and 1.43 MPa, and fluid permeability of the order of 10-13 m4/(N∙s). The permeability decreased as the deformation was increased above a strain level of about 10%, indicating that the interstitial space between fibrils of the corneal stromal matrix was reduced under the effect of strong compression. This effect may play a major role in determining the observed rate-dependent non-linear stress-strain response of the anterior cornea, which underlies the shape and optical properties of the tissue.
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