ArticlePLoS genetics2018
Adaptive genome duplication affects patterns of molecular evolution in Saccharomyces cerevisiae.
Article in PLoS genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed.
- Pervasive weak incompatibilities shape phenotypic variation and genome evolution in yeast hybrids.Nature communications · 2026Article
- Prevalence, distribution, and mechanisms of genetic dominance in the yeast mating pathway.Genetics · 2026Article
- Towards a unified model of aneuploid karyotype dynamics.PLoS genetics · 2026Article
- Evolutionary responses to increased opportunity for sexual selection in yeast.BMC ecology and evolution · 2026Article
- Repeated losses of self-fertility shaped heterozygosity and polyploidy in yeast evolution.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Weak pervasive incompatibilities and compensatory adaptation drive hybrid genome evolution in yeast.bioRxiv : the preprint server for biology · 2026Article
- Linkage-aware inference of fitness from short-read time-series genomic data.bioRxiv : the preprint server for biology · 2026Article
- Linkage-aware inference of fitness from short-read time-series genomic data.Virus evolution · 2026Article
- Prevalence, distribution, and mechanisms of genetic dominance in the yeast mating pathway.bioRxiv : the preprint server for biology · 2025Article
- Evolutionary responses to increased opportunity for sexual selection in yeast.bioRxiv : the preprint server for biology · 2025Article
- Contrasting mutation patterns in haploid and diploid cells from two yeast species.bioRxiv : the preprint server for biology · 2025Article
- Gene Family Expansions Provide Molecular Flexibility Required for Context-Dependent Species Interactions.Ecology letters · 2025Article
- Single-cell imaging of protein dynamics of paralogs reveals sources of gene retention.iScience · 2025Article
- Genetic Predisposition Toward Multicellularity in Chlamydomonas reinhardtii.Genome biology and evolution · 2025Article
- A high-resolution two-step evolution experiment in yeast reveals a shift from pleiotropic to modular adaptation.PLoS biology · 2024Article
- Impact of whole-genome duplications on structural variant evolution in Cochlearia.Nature communications · 2024Article
- Ploidy evolution in a wild yeast is linked to an interaction between cell type and metabolism.PLoS biology · 2023Article
- Contribution of Spontaneous Mutations to Quantitative and Molecular Variation at the Highly Repetitive rDNA Locus in Yeast.Genome biology and evolution · 2023Article
- Identifying Targets of Selection in Laboratory Evolution Experiments.Journal of molecular evolution · 2023Review
- Adaptive responses of yeast strains tolerant to acidic pH, acetate, and supraoptimal temperature.Applied microbiology and biotechnology · 2023Article
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5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genome duplications are important evolutionary events that impact the rate and spectrum of beneficial mutations and thus the rate of adaptation. Laboratory evolution experiments initiated with haploid Saccharomyces cerevisiae cultures repeatedly experience whole-genome duplication (WGD). We report recurrent genome duplication in 46 haploid yeast populations evolved for 4,000 generations. We find that WGD confers a fitness advantage, and this immediate fitness gain is accompanied by a shift in genomic and phenotypic evolution. The presence of ploidy-enriched targets of selection and structural variants reveals that autodiploids utilize adaptive paths inaccessible to haploids. We find that autodiploids accumulate recessive deleterious mutations, indicating an increased susceptibility for nonadaptive evolution. Finally, we report that WGD results in a reduced adaptation rate, indicating a trade-off between immediate fitness gains and long-term adaptability.
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