ArticleAutophagy2018
A ubiquitin-dependent mitophagy complex maintains mitochondrial function and insulin secretion in beta cells.
Article in Autophagy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Icaritin ameliorates mitochondrial dysfunction and autophagy impairment in cellular models of Alzheimer's disease.Frontiers in aging neuroscience · 2026Article
- Quercetin as a multifaceted neuroprotective agent against cerebral ischaemia-reperfusion injury: mechanisms and therapeutic potential.Frontiers in pharmacology · 2026Review
- Mitochondrial quality control in diabetes mellitus and complications: molecular mechanisms and therapeutic strategies.Cell death & disease · 2025Review
- Retrograde mitochondrial signaling governs the identity and maturity of metabolic tissues.Science (New York, N.Y.) · 2025Article
- Hypermethylation of Ring finger protein 41 promoter is associated with early hepatitis B virus-related cirrhosis.Frontiers in medicine · 2025Article
- Honokiol relieves hippocampal neuronal damage in Alzheimer's disease by activating the SIRT3-mediated mitochondrial autophagy.CNS neuroscience & therapeutics · 2024Article
- A noncanonical E3 ubiquitin ligase RNF41-mediated MYO1C stability promotes prostate cancer metastasis by inducing actin remodeling.Oncogene · 2024Article
- A heterozygous germline deletion within USP8 causes severe neurodevelopmental delay with multiorgan abnormalities.Journal of human genetics · 2024Article
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- Mitochondrial proteotoxicity: implications and ubiquitin-dependent quality control mechanisms.Cellular and molecular life sciences : CMLS · 2022Review
- Decreased PGC1β expression results in disrupted human erythroid differentiation, impaired hemoglobinization and cell cycle exit.Scientific reports · 2021Article
- A Selective Look at Autophagy in Pancreatic β-Cells.Diabetes · 2021Review
- Mitophagy protects β cells from inflammatory damage in diabetes.JCI insight · 2020Article
- Ubiquitin-specific protease 8 (USP8/UBPy): a prototypic multidomain deubiquitinating enzyme with pleiotropic functions.Biochemical Society transactions · 2019Review
- Bioinformatics analysis of hepatic gene expression profiles in type 2 diabetes mellitus.Experimental and therapeutic medicine · 2019Article
- Visualization of Endogenous Mitophagy Complexes In Situ in Human Pancreatic Beta Cells Utilizing Proximity Ligation Assay.Journal of visualized experiments : JoVE · 2019Article
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2 authors at 1 institution in 1 country.
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Abstract
Mitochondrial autophagy or mitophagy is a key component of mitochondrial quality control, which is necessary to maintain cellular bioenergetics. Pancreatic islet β-cells, which release insulin in response to circulating blood glucose levels, are particularly susceptible to mitochondrial dysfunction due to their high metabolic activity and energy requirements for insulin processing, maturation, and secretion. Therefore, dysregulated mitophagy has drawn interest in the etiology of β-cell failure in diabetes. We demonstrate that the pivotal β-cell mitophagy regulator, CLEC16A, is an E3 ligase that forms a ubiquitin-dependent tripartite complex with RNF41/NRDP1 and USP8. Maintenance of the CLEC16A-RNF41-USP8 mitophagy complex is necessary for maximal cellular respiration and insulin secretion. Further, we observe that diabetogenic metabolic stressors, including elevated glucose and fatty acids, destabilize the CLEC16A-RNF41-USP8 complex and lead to β-cell apoptosis. Thus, the β-cell mitophagy pathway requires ubiquitin signals to stabilize the CLEC16A-RNF41-USP8 complex and maintain mitochondrial quality control.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.