Evidence map›Paper›PMID 29799514›Full record

ArticleInternational journal of molecular sciences2018

Increased Phenacetin Oxidation upon the L382V Substitution in Cytochrome P450 1A2 is Associated with Altered Substrate Binding Orientation.

Qingbiao Huang, Grazyna D Szklarz

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Four Decades of Cytochrome P450 2B Research: From Protein Adducts to Protein Structures and Beyond.Drug metabolism and disposition: the biological fate of chemicals · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Qingbiao HuangDepartment of Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, WV 26506, USA. tommyqbhuang@gmail.com.
Grazyna D SzklarzDepartment of Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, WV 26506, USA. gszklarz@hsc.wvu.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Leucine382 of cytochrome P450 1A2 (CYP1A2) plays an important role in binding and

Indexed as

Amino Acid SubstitutionMutationCatalytic DomainCloning, MolecularCytochrome P-450 CYP1A2Escherichia coliGene ExpressionGenetic VectorsHumansKineticsModels, MolecularOxidation-ReductionPhenacetinProtein BindingProtein Conformation, alpha-HelicalProtein Conformation, beta-StrandCYP1A2 protein, humanCytochrome P-450 CYP1A2PhenacetinRecombinant Fusion ProteinsCYP1A2CYPscytochromes P450P450 mutantsphenacetin oxidationT1 NMR

Identifiers

PMID29799514
PMCPMC6032418

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.