ArticleMicrobiologyOpen2019
Virulence of Melissococcus plutonius and secondary invaders associated with European foulbrood disease of the honey bee.
Article in MicrobiologyOpen, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 55 citations in OpenAlex.
- Virulence Associated Morphology of Different Strains of Melissococcus plutonius, a Brood Pathogen of Honey Bees.Environmental microbiology reports · 2026Article
- Honey-derivedVirulence · 2025Article
- Friend or foe? Concentration of a commensal microbe induces distinct responses in developing honey bees exposed to field-realistic pesticide concentrations.FEMS microbiology ecology · 2025Article
- Ecology and Pathogenicity for Honey Bee Brood of Recently Described Paenibacillus melissococcoides and Comparison With Paenibacillus dendritiformis, Paenibacillus thiaminolyticus.Environmental microbiology reports · 2025Article
- Article
- Epidemiological study for detection of the main and secondary agents of European foulbrood disease in the apiaries of Iran.Veterinary research forum : an international quarterly journal · 2025Article
- Higher prevalence of sacbrood virus in Apis mellifera (Hymenoptera: Apidae) colonies after pollinating highbush blueberries.Journal of economic entomology · 2024Article
- Prevalence of pathogens in honey bee colonies and association with clinical signs in southwestern Quebec, Canada.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2024Article
- IPM Strategy to Control EFB inVeterinary sciences · 2024Article
- Revisiting the role of pathogen diversity and microbial interactions in honeybee susceptibility and treatment ofFrontiers in veterinary science · 2024Review
- Atypical Melissococcus plutonius strains: their characteristics, virulence, epidemiology, and mysteries.The Journal of veterinary medical science · 2023Review
- Influence of Honey bee Nutritive Jelly Type and Dilution on its Bactericidal Effect on Melissococcus plutonius, the Etiological Agent of European Foulbrood.Microbial ecology · 2023Article
- Population genetic diversity and dynamics of the honey bee brood pathogen Melissococcus plutonius in a region with high prevalence.Journal of invertebrate pathology · 2023Article
- A high-throughput sequencing survey characterizing European foulbrood disease and Varroosis in honey bees.Scientific reports · 2023Article
- In the battle of the disease: a transcriptomic analysis of European foulbrood-diseased larvae of the Western honey bee (Apis mellifera).BMC genomics · 2022Article
- Investigation ofThe Canadian veterinary journal = La revue veterinaire canadienne · 2022Article
- Evaluating approved and alternative treatments against an oxytetracycline-resistant bacterium responsible for European foulbrood disease in honey bees.Scientific reports · 2022Article
- Review
- A novel multiplex PCR assay to detect and distinguish between different types of Paenibacillus larvae and Melissococcus plutonius, and a survey of foulbrood pathogen contamination in Japanese honey.The Journal of veterinary medical science · 2022Article
- The role of honey in the ecology of the hive: Nutrition, detoxification, longevity, and protection against hive pathogens.Frontiers in nutrition · 2022Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
European foulbrood is a globally distributed brood disease affecting honey bees. It may lead to lethal infections of larvae and, in severe cases, even to colony collapse. Lately, a profound genetic and phenotypic diversity was documented for the causative agent Melissococcus plutonius. However, experimental work on the impact of diverse M. plutonius strains on hosts with different genetic background is completely lacking and the role of secondary invaders is poorly understood. Here, we address these issues and elucidate the impact and interaction of both host and pathogen on one another. Moreover, we try to unravel the role of secondary bacterial invasions in foulbrood-diseased larvae. We employed in vitro infections with honey bee larvae from queens with different genetic background and three different M. plutonius strains. Larvae infection experiments showed host-dependent survival dynamics although M. plutonius strain 49.3 consistently had the highest virulence. This pattern was also reflected in significantly reduced weights of 49.3 strain-infected larvae compared to the other treatments. No difference was found in groups additionally inoculated with a secondary invader (Enterococcus faecalis or Paenibacillus alvei) neither in terms of larval survival nor weight. These results suggest that host background contributes markedly to the course of the disease but virulence is mainly dependent on pathogen genotype. Secondary invaders following a M. plutonius infection do not increase disease lethality and therefore may just be a colonization of weakened and immunodeficient, or dead larvae.
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