ArticleScience (New York, N.Y.)2018
High parasite diversity accelerates host adaptation and diversification.
Article in Science (New York, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
78 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Parasitism shapes selection by drastically reducing host fitness and increasing host fitness variation.Biology letters · 2022Pooled it
- Nasal Mites of Kelp Gulls (Larus dominicanus) in Brazil: Geographic Distribution and Parasitological Indices.Acta parasitologica · 2026Article
- Parasites constrain within-population diversification while accelerating between-population divergence in an RNA replication system.Molecular biology and evolution · 2026Article
- Article
- A qPCR-Based Screening Platform for Exploratory Assessment of Phage Training Outcomes inViruses · 2026Article
- Assembly, architecture and functional roles of microbial surface layers.Nature reviews. Microbiology · 2026Review
- Eco-evolutionary responses to plasmid-dependent phage constrain the spread of multidrug-resistance plasmids.The ISME journal · 2026Article
- Rapid adaptation accelerates competitive suppression in a parasite community.The ISME journal · 2026Article
- Implementation and comparison of two concentration methods to detect and characterize bacteriophages and bacterial hosts from large drinking water samples.Environmental microbiome · 2025Article
- Community Complexity Does Not Weaken Pairwise Coevolution in a Soil Bacterial Community.Ecology letters · 2025Article
- Parasite-mediated inbreeding depression in wild red deer.Heredity · 2025Article
- A Conceptual Disease Cycle Model to Link the Size of Past and Future Epidemics.Ecology and evolution · 2025Review
- Novel Giant Phages vB_AerVM_332-Vera and vB_AerVM_332-Igor and Siphophage vB_AerVS_332-Yulya Infecting the SameViruses · 2025Article
- Host-virus coevolution drives soil microbial function succession along a millennium land reclamation chronosequence.Journal of advanced research · 2025Article
- Factors Affecting Phage-Bacteria Coevolution Dynamics.Viruses · 2025Review
- Eco-evolutionary robustness of wild bacterial communities to experimental perturbation.The ISME journal · 2025Article
- Within-host competition causes pathogen molecular evolution and perpetual microbiota dysbiosis.The ISME journal · 2025Article
- The arms race in bacteria-phage interaction: deciphering bacteria defense and phage anti-defense mechanisms through metagenomics.Frontiers in microbiology · 2025Review
- Diverse phage communities are maintained stably on a clonal bacterial host.Science (New York, N.Y.) · 2024Article
- Birds in arid regions have depauperate louse communities: Climate change implications?Ecology and evolution · 2024Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Host-parasite species pairs are known to coevolve, but how multiple parasites coevolve with their host is unclear. By using experimental coevolution of a host bacterium and its viral parasites, we revealed that diverse parasite communities accelerated host evolution and altered coevolutionary dynamics to enhance host resistance and decrease parasite infectivity. Increases in parasite diversity drove shifts in the mode of selection from fluctuating (Red Queen) dynamics to predominately directional (arms race) dynamics. Arms race dynamics were characterized by selective sweeps of generalist resistance mutations in the genes for the host bacterium's cell surface lipopolysaccharide (a bacteriophage receptor), which caused faster molecular evolution within host populations and greater genetic divergence among populations. These results indicate that exposure to multiple parasites influences the rate and type of host-parasite coevolution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.