ArticleGenome research2018
Evaluating recovery potential of the northern white rhinoceros from cryopreserved somatic cells.
Article in Genome research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 51 citations in OpenAlex.
- Review
- Chromosome-Scale Genome Architecture and Historical Demography of the Southern White Rhinoceros.Biology · 2026Article
- De-extinction of the Northern white rhinoceros (Ceratotherium simum cottoni).The Journal of reproduction and development · 2026Review
- Biobanking biodiversity: recent strategies, challenges, and opportunities.The Journal of reproduction and development · 2026Review
- Genomic map of the functionally extinct northern white rhinoceros (Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Identification and Preliminary Analysis of Granulosa Cell Biomarkers to Predict Oocyte In Vitro Maturation Outcome in the Southern White Rhinoceros (Animals : an open access journal from MDPI · 2024Article
- Demography and environment modulate the effects of genetic diversity on extinction risk in a butterfly metapopulation.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Genetic load and viability of a future restored northern white rhino population.Evolutionary applications · 2024Article
- Genomics, Population Divergence, and Historical Demography of the World's Largest and Endangered Butterfly, The Queen Alexandra's Birdwing.Genome biology and evolution · 2023Article
- Knockdown of YY1 InhibitsInternational journal of molecular sciences · 2022Article
- Whole-genome resequencing of Chinese pangolins reveals a population structure and provides insights into their conservation.Communications biology · 2022Article
- Naïve-like pluripotency to pave the way for saving the northern white rhinoceros from extinction.Scientific reports · 2022Article
- Historical population declines prompted significant genomic erosion in the northern and southern white rhinoceros (Ceratotherium simum).Molecular ecology · 2021Article
- Reference genome and demographic history of the most endangered marine mammal, the vaquita.Molecular ecology resources · 2021Article
- Genomic insights into the conservation status of the world's last remaining Sumatran rhinoceros populations.Nature communications · 2021Article
- Rewinding Extinction in the Northern White Rhinoceros: Genetically Diverse Induced Pluripotent Stem Cell Bank for Genetic Rescue.Stem cells and development · 2021Article
- What animals can teach us about evolution, the human genome, and human disease.Upsala journal of medical sciences · 2020Review
- De-Extinction.Genes · 2018Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The critically endangered northern white rhinoceros is believed to be extinct in the wild, with the recent death of the last male leaving only two remaining individuals in captivity. Its extinction would appear inevitable, but the development of advanced cell and reproductive technologies such as cloning by nuclear transfer and the artificial production of gametes via stem cells differentiation offer a second chance for its survival. In this work, we analyzed genome-wide levels of genetic diversity, inbreeding, population history, and demography of the white rhinoceros sequenced from cryopreserved somatic cells, with the goal of informing how genetically valuable individuals could be used in future efforts toward the genetic rescue of the northern white rhinoceros. We present the first sequenced genomes of the northern white rhinoceros, which show relatively high levels of heterozygosity and an average genetic divergence of 0.1% compared with the southern subspecies. The two white rhinoceros subspecies appear to be closely related, with low genetic admixture and a divergent time <80,000 yr ago. Inbreeding, as measured by runs of homozygosity, appears slightly higher in the southern than the northern white rhinoceros. This work demonstrates the value of the northern white rhinoceros cryopreserved genetic material as a potential gene pool for saving this subspecies from extinction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.