Evidence map›Paper›PMID 29798745›Full record

Trial reportEmerging infectious diseases2018

Therapeutic and Transmission-Blocking 
Efficacy of Dihydroartemisinin/Piperaquine and Chloroquine against Plasmodium vivax Malaria, Cambodia.

Jean Popovici, Amelie Vantaux, Lyse Primault, Reingsey Samreth, Eak Por Piv, Sophalai Bin, Saorin Kim, Dysoley Lek, David Serre, Didier Menard

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Emerging infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. The Impact ofJournal of parasitology research · 2026
    Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Declining Burden ofThe American journal of tropical medicine and hygiene · 2020
    Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jean Popovici
Amelie Vantaux
Lyse Primault
Reingsey Samreth
Eak Por Piv
Sophalai Bin
Saorin Kim
Dysoley Lek
David Serre
Didier Menard

Funding

Genomic Analyses of Plasmodium vivax Responses to Antimalarial Drugs in CambodiaR01AI103228 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI SERRE, DAVID · 2013 to 2017
$1.8M
NIAID NIH HHS R01 AI103228
6 · The paper itself

Abstract

We assessed the efficacy of standard 3-day courses of chloroquine and dihydroartemisinin/piperaquine against Plasmodium vivax malaria. Compared with chloroquine, dihydroartemisinin/piperaquine was faster in clearing asexual P. vivax parasites and blocking human-to-mosquito transmission. This drug combination was also more effective in preventing potential recurrences for >2 months.

Indexed as

AdolescentAdultAntimalarialsArtemisininsChloroquineDrug CombinationsFemaleHumansMalaria, VivaxMaleMiddle AgedPiperazinesPlasmodium vivaxQuinolinesYoung AdultAntimalarialsArtemisininsartenimolChloroquineDrug CombinationspiperaquinePiperazinesQuinolinesAnopheles dirusCambodiachloroquineDHA/PPQdihydroartemisinin/piperaquineefficacyfeeding assaysinfectivitymalariamosquitoesparasitesPlasmodium vivaxtherapeutic efficacytransmissiontransmission-blocking efficacy

Identifiers

PMID29798745
PMCPMC6056113

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.