Evidence map›Paper›PMID 29798633›Full record

ArticleZhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery2017

[Transfection of lentivirus-bone morphogenetic protein 2 and lentivirus-inhibitor of differentiation 1 into nucleus pulposus for delaying intervertebral disc degeneration in an

Tao Lei, Zhengxue Quan, Yuan Zhang, Xiaoji Luo, Chang Yu, Qiang Zhou

Open access · greenAbstract read
In one paragraph

Article in Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 71% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. [Effects of lentivirus-mediated insulin-like growth factor 1 and platelet derived growth factor genes on nucleus pulposus tissue of human degenerated intervertebral disc].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Tao LeiDepartment of Orthopeadics, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, P.R.China.
Zhengxue QuanDepartment of Orthopeadics, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, P.R.China.quanzx18@126.com.
Yuan ZhangDepartment of Orthopeadics, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, P.R.China.
Xiaoji LuoDepartment of Orthopeadics, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, P.R.China.
Chang YuDepartment of Orthopeadics, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, P.R.China.
Qiang ZhouDepartment of Orthopeadics, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, P.R.China.
The Affiliated Yongchuan Hospital of Chongqing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To investigate if the course of intervertebral disc degeneration (IDD) is delayed by injecting lentivirus (Lv) vector carrying bone morphogenetic protein 2 (BMP-2) and inhibitor of differentiation 1 (Id1) genes directly into the nucleus pulposus. Methods: Thirty-two New Zealand white rabbits, 2.0-2.5 kg in weight and 4 months in age, were used to establish the IDD models at L Results: T2-mapping MRI demonstrated that there was no significant difference in the T2 value between different groups at immediate and 2 weeks after injection ( Conclusion: Combined application of Lv-BMP-2 and Lv-Id1 can delay IDD changes in rabbit IDD models.

Indexed as

Genetic TherapyTransfectionAnimalsBone Morphogenetic Protein 2Disease Models, AnimalIntervertebral DiscIntervertebral Disc DegenerationLentivirusNucleus PulposusRabbitsRandom AllocationBone Morphogenetic Protein 2bone morphogenetic protein 2gene therapyinhibitor of differentiation 1Intervertebral disc degeneration

Identifiers

PMID29798633
PMCPMC9548026
OpenAlexW2949332334

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.