Evidence map›Paper›PMID 29798594›Full record

ArticleZhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery2017

[Effect of ursolic acid on proliferation and apoptosis of human osteosarcoma cell line U2-OS].

Shifu Huang, Feng Cai, Zhaoxian Cheng, Rongping Zhou, Liang Hao

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 79% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Shifu HuangDepartment of Orthopaedics, the People's Hospital of Jishui County, Jishui Jiangxi, 331600, P.R.China.
Feng CaiDepartment of Orthopaedics, the Second Affiliated Hospital of Nanchang University, Nanchang Jiangxi, 33006, P.R.China.
Zhaoxian ChengDepartment of Orthopaedics, the Second Affiliated Hospital of Nanchang University, Nanchang Jiangxi, 33006, P.R.China.
Rongping ZhouDepartment of Orthopaedics, the Second Affiliated Hospital of Nanchang University, Nanchang Jiangxi, 33006, P.R.China.
Liang HaoDepartment of Orthopaedics, the Second Affiliated Hospital of Nanchang University, Nanchang Jiangxi, 33006, P.R.China.haoliang201@163.com.
Nanchang University · CNPeking University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To investigate the effect of ursolic acid on the proliferation and apoptosis of human osteosarcoma cell line U2-OS and analyze its mechanism. Methods: Human osteosarcoma cell line U2-OS was divided into 4 groups, which was cultured with ursolic acid of 0, 10, 20, and 40 μmol/L, respectively. At 0, 24, 48, and 72 hours after being cultured, the cell proliferation ability was detected by cell counting kit 8 (CCK-8). At 48 hours, the effects of ursolic acid on cell cycle and apoptosis of U2-OS cells were measured by flow cytometry. Besides, the expressions of cyclin D1 and Caspase-3 were detected by real-time fluorescent quantitative PCR and Western blot. Results: CCK-8 tests showed that the absorbance ( Conclusion: Ursolic acid can effectively inhibit the proliferation of osteosarcoma cell line U2-OS, induce the down-regulation of cyclin D1 expression leading to G

Indexed as

ApoptosisBone NeoplasmsCell Line, TumorCell ProliferationHumansOsteosarcomaTriterpenesUrsolic AcidTriterpenesUrsolic Acidcell apoptosiscell proliferationosteosarcomaU2-OS cellsUrsolic acid

Identifiers

PMID29798594
PMCPMC8632589
OpenAlexW3025562305

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.