ArticleHuman brain mapping2018
Genetic load determines atrophy in hand cortico-striatal pathways in presymptomatic Huntington's disease.
Article in Human brain mapping, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- The role of white matter microstructure in the association between childhood maltreatment and adult post-traumatic symptoms.Molecular psychiatry · 2026Article
- Reconstructing the somatotopic organization of the corticospinal tract remains a challenge for modern tractography methods.Human brain mapping · 2023Article
- Progressive alterations in white matter microstructure across the timecourse of Huntington's disease.Brain and behavior · 2023Article
- Sleep Quality Disturbances Are Associated with White Matter Alterations in Veterans with Post-Traumatic Stress Disorder and Mild Traumatic Brain Injury.Journal of clinical medicine · 2023Article
- Comprehensive shape analysis of the cortex in Huntington's disease.Human brain mapping · 2023Article
- HOA2.0-ComPaRe: A next generation Harvard-Oxford Atlas comparative parcellation reasoning method for human and macaque individual brain parcellation and atlases of the cerebral cortex.Frontiers in neuroanatomy · 2022Article
- Creation of a novel trigeminal tractography atlas for automated trigeminal nerve identification.NeuroImage · 2020Article
- Diffusion imaging in Huntington's disease: comprehensive review.Journal of neurology, neurosurgery, and psychiatry · 2020Review
- Article
- Genetic load determines atrophy in hand cortico-striatal pathways in presymptomatic Huntington's disease.Human brain mapping · 2018Article
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Authors and funding
12 authors at 6 institutions in 2 countries.
Funding
Abstract
Huntington's disease (HD) is an inherited neurodegenerative disorder that causes progressive breakdown of striatal neurons. Standard white matter integrity measures like fractional anisotropy and mean diffusivity derived from diffusion tensor imaging were analyzed in prodromal-HD subjects; however, they studied either a whole brain or specific subcortical white matter structures with connections to cortical motor areas. In this work, we propose a novel analysis of a longitudinal cohort of 243 prodromal-HD individuals and 88 healthy controls who underwent two or more diffusion MRI scans as part of the PREDICT-HD study. We separately trace specific white matter fiber tracts connecting the striatum (caudate and putamen) with four cortical regions corresponding to the hand, face, trunk, and leg motor areas. A multi-tensor tractography algorithm with an isotropic volume fraction compartment allows estimating diffusion of fast-moving extra-cellular water in regions containing crossing fibers and provides quantification of a microstructural property related to tissue atrophy. The tissue atrophy rate is separately analyzed in eight cortico-striatal pathways as a function of CAG-repeats (genetic load) by statistically regressing out age effect from our cohort. The results demonstrate a statistically significant increase in isotropic volume fraction (atrophy) bilaterally in hand fiber connections to the putamen with increasing CAG-repeats, which connects the genetic abnormality (CAG-repeats) to an imaging-based microstructural marker of tissue integrity in specific white matter pathways in HD. Isotropic volume fraction measures in eight cortico-striatal pathways are also correlated significantly with total motor scores and diagnostic confidence levels, providing evidence of their relevance to HD clinical presentation.
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