Evidence map›Paper›PMID 29797516›Full record

ReviewEuropean journal of clinical investigation2018

Exercising the hepatobiliary-gut axis. The impact of physical activity performance.

Emilio Molina-Molina, Raquel Lunardi Baccetto, David Q-H Wang, Ornella de Bari, Marcin Krawczyk, Piero Portincasa

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in European journal of clinical investigation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 3 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 3 syntheses or guidelines pooled it, 61 citations in OpenAlex.

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  9. The Post-Cholecystectomy Gut Microbiota Follows a Time-Varying Change-A Pilot Study.JGH open : an open access journal of gastroenterology and hepatology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 4 countries.

Emilio Molina-MolinaClinica Medica "A. Murri", Department of Biomedical Sciences & Human Oncology, University of Bari Medical School, Bari, Italy.ORCID http://orcid.org/0000-0003-4390-5275
Raquel Lunardi BaccettoClinica Medica "A. Murri", Department of Biomedical Sciences & Human Oncology, University of Bari Medical School, Bari, Italy.ORCID http://orcid.org/0000-0003-0437-9065
David Q-H WangDepartment of Medicine, Division of Gastroenterology and Liver Diseases, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY, USA.ORCID http://orcid.org/0000-0002-5439-7651
Ornella de BariClinica Medica "A. Murri", Department of Biomedical Sciences & Human Oncology, University of Bari Medical School, Bari, Italy.ORCID http://orcid.org/0000-0003-2967-6859
Marcin KrawczykDepartment of Medicine II, Saarland University Medical Center, Homburg, Germany.ORCID http://orcid.org/0000-0002-0113-0777
Piero PortincasaClinica Medica "A. Murri", Department of Biomedical Sciences & Human Oncology, University of Bari Medical School, Bari, Italy.ORCID http://orcid.org/0000-0001-5359-1471
University of Bari Aldo Moro · ITAlbert Einstein College of Medicine · USMedical University of Warsaw · PL

Funding

Apolipoprotein A5 and Gallstone FormationR01DK114516 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI WANG, DAVID Q · 2018 to 2021
$1.5M
NIDDK NIH HHS R01 DK114516
6 · The paper itself

Abstract

backgroundPhysical inactivity puts the populations at risk of several health problems, while regular physical activity brings beneficial effects on cardiovascular disease, mortality and other health outcomes, including obesity, glycaemic control and insulin resistance. The hepatobiliary tract is greatly involved in several metabolic aspects which include digestion and absorption of nutrients in concert with intestinal motility, bile acid secretion and flow across the enterohepatic circulation and intestinal microbiota. Several metabolic abnormalities, including nonalcoholic fatty liver as well as cholesterol cholelithiasis, represent two conditions explained by changes of the aforementioned pathways. MATERIALS AND

methodsThis review defines different training modalities and discusses the effects of physical activity in two metabolic disorders, that is nonalcoholic fatty liver disease (NAFLD) and cholelithiasis. Emphasis is given to pathogenic mechanisms involving intestinal bile acids, microbiota and inflammatory status.

resultsA full definition of physical activity includes the knowledge of aerobic and endurance exercise, metabolic equivalent tasks, duration, frequency and intensity, beneficial and harmful effects. Physical activity influences the hepatobiliary-gut axis at different levels and brings benefits to fat distribution, liver fat and gallbladder disease while interacting with bile acids as signalling molecules, intestinal microbiota and inflammatory changes in the body.

conclusionsSeveral beneficial effects of physical activity are anticipated on metabolic disorders linking liver steatosis, gallstone disease, gut motility, enterohepatic circulation of signalling bile acids in relation to intestinal microbiota and inflammatory changes.

Indexed as

AdultAgedBile Acids and SaltsBiliary TractCholecystitisCholelithiasisExerciseFemaleHealthy LifestyleHumansMaleMicrobiotaMiddle AgedNon-alcoholic Fatty Liver DiseaseBile Acids and Saltsbile acidsfarnesoid X receptorgallstone diseaseG protein-coupled bile acid receptor-1gut microbiotanonalcoholic fatty liver disease

Identifiers

PMID29797516
PMCPMC8118139
OpenAlexW2803376634

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.