ArticleNeuropathology and applied neurobiology2019
Differential insular cortex subregional vulnerability to α-synuclein pathology in Parkinson's disease and dementia with Lewy bodies.
Article in Neuropathology and applied neurobiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29 citing papers in PubMed, 53 citations in OpenAlex.
- Redefining Non-Motor Symptoms in Parkinson's Disease.Journal of personalized medicine · 2025Review
- Bundle-specific tractography approach for identifying white matter microstructural changes following traumatic brain injury in rats: An EpiBioS4Rx study.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Segmentation of supragranular and infragranular layers in ultra-high-resolution 7T ex vivo MRI of the human cerebral cortex.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Neuroinflammation is associated with Alzheimer's disease co-pathology in dementia with Lewy bodies.Acta neuropathologica communications · 2024Article
- Spatial transcriptomics reveals molecular dysfunction associated with cortical Lewy pathology.Nature communications · 2024Article
- LRP10 and α-synuclein transmission in Lewy body diseases.Cellular and molecular life sciences : CMLS · 2024Article
- Aggregate-prone brain regions in Parkinson's disease are rich in unique N-terminus α-synuclein conformers with high proteolysis susceptibility.NPJ Parkinson's disease · 2024Article
- Serotonin transporter density in isolated rapid eye movement sleep behavioral disorder.Frontiers in sleep · 2024Article
- Unveiling MRI markers for Parkinson's Disease: GABAergic dysfunction and cortical changes.NeuroImage. Clinical · 2024Article
- Segmentation of supragranular and infragranular layers in ultra-high resolution 7TbioRxiv : the preprint server for biology · 2023Article
- Exploring the prevalence of undetected bradyarrhythmia in dementia with Lewy bodies.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2023Article
- Subjective experience of time in dementia with Lewy bodies during COVID-19 lockdown.Current psychology (New Brunswick, N.J.) · 2023Article
- Axonal degeneration in the anterior insular cortex is associated with Alzheimer's co-pathology in Parkinson's disease and dementia with Lewy bodies.Translational neurodegeneration · 2022Article
- Prominent astrocytic alpha-synuclein pathology with unique post-translational modification signatures unveiled across Lewy body disorders.Acta neuropathologica communications · 2022Article
- Structural network topology and microstructural alterations of the anterior insula associate with cognitive and affective impairment in Parkinson's disease.Scientific reports · 2021Article
- Predicting Parkinson's disease trajectory using clinical and neuroimaging baseline measures.Parkinsonism & related disorders · 2021Article
- Experimental Models of Cognitive Impairment for Use in Parkinson's Disease Research: The Distance Between Reality and Ideal.Frontiers in aging neuroscience · 2021Review
- Von Economo Neurons - Primate-Specific or Commonplace in the Mammalian Brain?Frontiers in neural circuits · 2021Review
- The insula, a grey matter of tastes: a volumetric MRI study in dementia with Lewy bodies.Alzheimer's research & therapy · 2020Article
- Changes in gray matter volume and functional connectivity in dementia with Lewy bodies compared to Alzheimer's disease and normal aging: implications for fluctuations.Alzheimer's research & therapy · 2020Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThe insular cortex consists of a heterogenous cytoarchitecture and diverse connections and is thought to integrate autonomic, cognitive, emotional and interoceptive functions to guide behaviour. In Parkinson's disease (PD) and dementia with Lewy bodies (DLB), it reveals α-synuclein pathology in advanced stages. The aim of this study is to assess the insular cortex cellular and subregional vulnerability to α-synuclein pathology in well-characterized PD and DLB subjects.
methodsWe analysed postmortem insular tissue from 24 donors with incidental Lewy body disease, PD, PD with dementia (PDD), DLB and age-matched controls. The load and distribution of α-synuclein pathology and tyrosine hydroxylase (TH) cells were studied throughout the insular subregions. The selective involvement of von Economo neurons (VENs) in the anterior insula and astroglia was assessed in all groups.
resultsA decreasing gradient of α-synuclein pathology load from the anterior periallocortical agranular towards the intermediate dysgranular and posterior isocortical granular insular subregions was found. Few VENs revealed α-synuclein inclusions while astroglial synucleinopathy was a predominant feature in PDD and DLB. TH neurons were predominant in the agranular and dysgranular subregions but did not reveal α-synuclein inclusions or significant reduction in density in patient groups.
conclusionsOur study highlights the vulnerability of the anterior agranular insula to α-synuclein pathology in PD, PDD and DLB. Whereas VENs and astrocytes were affected in advanced disease stages, insular TH neurons were spared. Owing to the anterior insula's affective, cognitive and autonomic functions, its greater vulnerability to pathology indicates a potential contribution to nonmotor deficits in PD and DLB.
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