Evidence map›Paper›PMID 29797226›Full record

Trial reportCerebellum (London, England)2018

Short-Term Effects of Cerebellar tDCS on Standing Balance Performance in Patients with Chronic Stroke and Healthy Age-Matched Elderly.

Sarah B Zandvliet, Carel G M Meskers, Gert Kwakkel, Erwin E H van Wegen

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Cerebellum (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sarah B ZandvlietDepartment of Rehabilitation Medicine, VU University Medical Center, Amsterdam Neuroscience and Amsterdam Movement Sciences, Amsterdam, The Netherlands.
Carel G M MeskersDepartment of Rehabilitation Medicine, VU University Medical Center, Amsterdam Neuroscience and Amsterdam Movement Sciences, Amsterdam, The Netherlands.
Gert KwakkelDepartment of Rehabilitation Medicine, VU University Medical Center, Amsterdam Neuroscience and Amsterdam Movement Sciences, Amsterdam, The Netherlands.
Erwin E H van WegenDepartment of Rehabilitation Medicine, VU University Medical Center, Amsterdam Neuroscience and Amsterdam Movement Sciences, Amsterdam, The Netherlands. e.vanwegen@vumc.nl.ORCID http://orcid.org/0000-0002-7920-9995

Funding

Hersenstichting F2013(1)-41
6 · The paper itself

Abstract

Transcranial direct current stimulation (tDCS) may serve as an adjunct approach in stroke rehabilitation. The cerebellum could be a target during standing balance training due to its role in motor adaptation. We tested whether cerebellar tDCS can lead to short-term effects on standing balance performance in patients with chronic stroke. Fifteen patients with a chronic stroke were stimulated with anodal stimulation on the contra-lesional cerebellar hemisphere, ipsi-lesional cerebellar hemisphere, or sham stimulation, for 20 min with 1.5 mA in three sessions in randomized order. Ten healthy controls participated in two sessions with cerebellar stimulation ipsi-lateral to their dominant leg or sham stimulation. During stimulation, subjects performed a medio-lateral postural tracking task on a force platform. Standing balance performance was measured directly before and after each training session in several standing positions. Outcomes were center of pressure (CoP) amplitude and its standard deviation, and velocity and its standard deviation and range, subsequently combined into a CoP composite score (comp-score) as a qualitative outcome parameter. In the patient group, a decrease in comp-score in the tandem position was found after contra-lesional tDCS: β = - 0.25, CI = - 0.48 to - 0.03, p = 0.03. No significant differences in demographics and clinical characteristics were found between patients who responded (N = 10) and patients who did not respond (N = 5) to the stimulation. Contra-lesional cerebellar tDCS shows promise for improving standing balance performance. Exploration of optimal timing, dose, and the relation between qualitative parameters and clinical improvements are needed to establish whether tDCS can augment standing balance performance after stroke.

Indexed as

CerebellumPostural BalanceStroke RehabilitationTranscranial Direct Current StimulationBrain IschemiaCerebral HemorrhageChronic DiseaseFemaleHumansMaleMiddle AgedProof of Concept StudyStrokeTime FactorsCerebellumPostural balanceStrokeTranscranial direct current stimulation

Identifiers

PMID29797226
PMCPMC6132826

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.