Evidence map›Paper›PMID 29797183›Full record

ArticleMolecular neurobiology2019

Adenosine A

Marla Rivera-Oliver, Estefanía Moreno, Yocasta Álvarez-Bagnarol, Christian Ayala-Santiago, Nicole Cruz-Reyes, Gian Carlo Molina-Castro, Stefan Clemens, Enric I Canela, Sergi Ferré, Vicent Casadó and 1 more

Open access · greenAbstract read
In one paragraph

Article in Molecular neurobiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

  1. Putative Animal Models of Restless Legs Syndrome: A Systematic Review and Evaluation of Their Face and Construct Validity.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023
    Pooled it
  2. Review
  3. Article
  4. Astrocyte Regulation of Spinal Circuit Function.Journal of neurochemistry · 2026
    Review
  5. GPCR Heterodimers: Implications for Biased Signaling.Handbook of experimental pharmacology · 2026
    Review
  6. Adenosine in the Brain: Recent Progress on Detection, Function, and Translation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Heterobivalent Ligand for the Adenosine AJournal of medicinal chemistry · 2022
    Article
  15. Sleep, Narcolepsy, and Sodium Oxybate.Current neuropharmacology · 2022
    Article
  16. Review
  17. Heteromerization between αPharmacological research · 2021
    Article
  18. Adenosine APurinergic signalling · 2021
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Marla Rivera-OliverDepartment of Anatomy and Neurobiology and Institute of Neurobiology, University of Puerto Rico, Medical Sciences, Rio Piedras and Cayey Campuses, San Juan, 00936, Puerto Rico.
Estefanía MorenoCenter for Biomedical Research in Neurodegenerative Diseases Network (CIBERNED) and Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, Institute of Biomedicine of the University of Barcelona, University of Barcelona, 08028, Barcelona, Spain.
Yocasta Álvarez-BagnarolDepartment of Anatomy and Neurobiology and Institute of Neurobiology, University of Puerto Rico, Medical Sciences, Rio Piedras and Cayey Campuses, San Juan, 00936, Puerto Rico.
Christian Ayala-SantiagoDepartment of Anatomy and Neurobiology and Institute of Neurobiology, University of Puerto Rico, Medical Sciences, Rio Piedras and Cayey Campuses, San Juan, 00936, Puerto Rico.
Nicole Cruz-ReyesDepartment of Anatomy and Neurobiology and Institute of Neurobiology, University of Puerto Rico, Medical Sciences, Rio Piedras and Cayey Campuses, San Juan, 00936, Puerto Rico.
Gian Carlo Molina-CastroDepartment of Anatomy and Neurobiology and Institute of Neurobiology, University of Puerto Rico, Medical Sciences, Rio Piedras and Cayey Campuses, San Juan, 00936, Puerto Rico.
Stefan ClemensDepartment of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC, 27834, USA.
Enric I CanelaCenter for Biomedical Research in Neurodegenerative Diseases Network (CIBERNED) and Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, Institute of Biomedicine of the University of Barcelona, University of Barcelona, 08028, Barcelona, Spain.
Sergi FerréIntegrative Neurobiology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Triad Technology Building, 333 Cassell Drive, Baltimore, MD, 21224, USA. sferre@intra.nida.nih.gov.ORCID http://orcid.org/0000-0002-1747-1779
Vicent CasadóCenter for Biomedical Research in Neurodegenerative Diseases Network (CIBERNED) and Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, Institute of Biomedicine of the University of Barcelona, University of Barcelona, 08028, Barcelona, Spain.
Manuel Díaz-RíosDepartment of Anatomy and Neurobiology and Institute of Neurobiology, University of Puerto Rico, Medical Sciences, Rio Piedras and Cayey Campuses, San Juan, 00936, Puerto Rico.
University of Puerto Rico, Medical Sciences Campus · PRBiomedical Research Networking Center on Neurodegenerative Diseases · ESEast Carolina University · USNational Institutes of Health · US

Funding

Upgrade Laboratories Facilities at UPR-Rio PiedrasR25GM061151 · NIGMS · UNIVERSITY OF PUERTO RICO RIO PIEDRAS · PI CARBALLEIRA, NESTOR MANUEL · 2001 to 2023
$32.5M
The Role of Sensory Input to Mammalian Locomotion After the Loss of supraspinal.P20GM103642 · NIGMS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI LASALDE-DOMINICCI, JOSE ANTONIO · 2013 to 2023
$20.6M
TRANSLATIONAL PROTEOMICS CENTERG12MD007600 · NIMHD · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI FERNANDEZ-REPOLLET, EMMA · 2012 to 2016
$11.0M
Division of Biological Infrastructure 1337284Generalitat de Catalunya 2014-SGR-1236Intramural NIH HHS Z99 DA999999Ministerio de Economía y Competitividad SAF2014-54840-RNIDA NIH HHS Intramural FundsNIGMS NIH HHS 1P20GM103642NIGMS NIH HHS P20 GM103642NIGMS NIH HHS R25 GM061151NIMHD NIH HHS 8G12-MD007600NIMHD NIH HHS G12 MD007600
6 · The paper itself

Abstract

While the role of the ascending dopaminergic system in brain function and dysfunction has been a subject of extensive research, the role of the descending dopaminergic system in spinal cord function and dysfunction is just beginning to be understood. Adenosine plays a key role in the inhibitory control of the ascending dopaminergic system, largely dependent on functional complexes of specific subtypes of adenosine and dopamine receptors. Combining a selective destabilizing peptide strategy with a proximity ligation assay and patch-clamp electrophysiology in slices from male mouse lumbar spinal cord, the present study demonstrates the existence of adenosine A

Indexed as

AdenosineCaffeineCells, CulturedDopamineHumansMotor NeuronsNeurons, EfferentReceptors, Dopamine D1Spinal CordSynaptic TransmissionAdenosineCaffeineDopamineReceptors, Dopamine D1Adenosine A1 receptorDopamine D1 receptorMotoneuronReceptor heteromersSpinal cord

Identifiers

PMID29797183
PMCPMC6252157
OpenAlexW2803570575

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.