ReviewEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society2018
Danger signals from mitochondrial DAMPS in trauma and post-injury sepsis.
Review in European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
- Early use of high-dose vitamin C is beneficial in treatment of sepsis.Irish journal of medical science · 2021Trial
- Formyl peptide receptor 1 agonism selectively suppresses mitochondria-driven neutrophil extracellular trap formation while preserving antibacterial immunity.Molecular medicine (Cambridge, Mass.) · 2026Article
- Characterization of lipidome alterations in a standardized porcine model with multiple trauma and hemorrhagic shock: Are they driven by hepatic injury?The journal of trauma and acute care surgery · 2025Article
- Kidneys on the Frontline: Nephrologists Tackling the Wilds of Acute Kidney Injury in Trauma Patients-From Pathophysiology to Early Biomarkers.Diagnostics (Basel, Switzerland) · 2025Review
- Earthing effects on mitochondrial function: ATP production and ROS generation.FEBS open bio · 2025Article
- Exploratory cluster analysis of IL2Ra and associated biomarkers and complications after blunt chest trauma.The journal of trauma and acute care surgery · 2025Article
- Hemorrhagic Shock and Mitochondria: Pathophysiology and Therapeutic Approaches.International journal of molecular sciences · 2025Review
- Revolution in sepsis: a symptoms-based to a systems-based approach?Journal of biomedical science · 2024Review
- What is the actual relationship between neutrophil extracellular traps and COVID-19 severity? A longitudinal study.Respiratory research · 2024Article
- Multifunctional Cationic Hyperbranched Polyaminoglycosides that Target Multiple Mediators for Severe Abdominal Trauma Management.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Clinical chorioamnionitis at term is characterized by changes in the plasma concentration of CHCHD2/MNRR1, a mitochondrial protein.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2023Article
- Mitochondrial-Derived Vesicles: The Good, the Bad, and the Ugly.International journal of molecular sciences · 2023Review
- IL-6 and cfDNA monitoring throughout COVID-19 hospitalization are accurate markers of its outcomes.Respiratory research · 2023Article
- Mitochondria-derived vesicles and their potential roles in kidney stone disease.Journal of translational medicine · 2023Review
- Mind body medicine: a modern bio-psycho-social model forty-five years after Engel.BioPsychoSocial medicine · 2023Article
- Mitochondrion-targeted antioxidant SkQ1 prevents rapid animal death caused by highly diverse shocks.Scientific reports · 2023Article
- Extracellular mitochondria drive CD8 T cell dysfunction in trauma by upregulating CD39.Thorax · 2023Article
- JMJD3 Is Required for Acute Pancreatitis and Pancreatitis-Associated Lung Injury.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- Neutrophil extracellular traps formation and clearance is enhanced in fever and attenuated in hypothermia.Frontiers in immunology · 2023Article
- Inflammation balance in skeletal muscle damage and repair.Frontiers in immunology · 2023Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
In all multicellular organisms, immediate host responses to both sterile and infective threat are initiated by very primitive systems now grouped together under the general term 'danger responses'. Danger signals are generated when primitive 'pattern recognition receptors' (PRR) encounter activating 'alarmins'. These molecular species may be of pathogenic infective origin (pathogen-associated molecular patterns) or of sterile endogenous origin (danger-associated molecular patterns). There are many sterile and infective alarmins and there is considerable overlap in their ability to activate PRR, but in all cases the end result is inflammation. It is the overlap between sterile and infective signals acting via a relatively limited number of PRR that generally underlies the great clinical similarity we see between sterile and infective systemic inflammatory responses. Mitochondria (MT) are evolutionarily derived from bacteria, and thus they sit at the crossroads between sterile and infective danger signal pathways. Many of the molecular species in mitochondria are alarmins, and so the release of MT from injured cells results in a wide variety of inflammatory events. This paper discusses the known participation of MT in inflammation and reviews what is known about how the major.
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