ArticleWorld journal of microbiology & biotechnology2018
Molecular profiling of mucosal tissue associated microbiota in patients manifesting acute exacerbations and remission stage of ulcerative colitis.
Article in World journal of microbiology & biotechnology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
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Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Is the microbiome the answer to inflammatory bowel disease: systematic review.Langenbeck's archives of surgery · 2025Pooled it
- Gut microbiome in chronic rheumatic and inflammatory bowel diseases: Similarities and differences.United European gastroenterology journal · 2019Pooled it
- Combined treatment with naringin and osthole ameliorates colitis through microbiota-amino acid metabolism and the JNK pathway.Natural products and bioprospecting · 2026Article
- The Degree of Mucosa-Associated Microecological Imbalance in Ulcerative Colitis Patients with Different Mayo Score and Its Relationship with Mucosal Mechanical Barrier Damage.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2025Article
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- Total alkaloids ofFrontiers in pharmacology · 2025Article
- A Novel Microbial Dysbiosis Index and Intestinal Microbiota-Associated Markers as Tools of Precision Medicine in Inflammatory Bowel Disease Paediatric Patients.International journal of molecular sciences · 2024Article
- Article
- Alterations in metabolome and microbiome: new clues on cathelicidin-related antimicrobial peptide alleviates acute ulcerative colitis.Frontiers in microbiology · 2024Article
- Aqueous extract ofFrontiers in microbiology · 2024Article
- Mitochondrial dysfunction promotes microbial composition that negatively impacts on ulcerative colitis development and progression.NPJ biofilms and microbiomes · 2023Article
- CRP in Outpatients with Inflammatory Bowel Disease Is Linked to the Blood Microbiota.International journal of molecular sciences · 2023Article
- Whole intestinal microbiota transplantation is more effective than fecal microbiota transplantation in reducing the susceptibility of DSS-induced germ-free mice colitis.Frontiers in immunology · 2023Article
- Alterations in metabolome and microbiome signatures provide clues to the role of antimicrobial peptide KT2 in ulcerative colitis.Frontiers in microbiology · 2023Article
- Article
- Fusobacterium nucleatum promotes colon cancer progression by changing the mucosal microbiota and colon transcriptome in a mouse model.World journal of gastroenterology · 2022Article
- Gegen Qinlian Decoction Alleviates Experimental Colitis and Concurrent Lung Inflammation by Inhibiting the Recruitment of Inflammatory Myeloid Cells and Restoring Microbial Balance.Journal of inflammation research · 2022Article
- Bin1 targeted immunotherapy alters the status of the enteric neurons and the microbiome during ulcerative colitis treatment.PloS one · 2022Article
- Immunoglobulin subtype-coated bacteria are correlated with the disease activity of inflammatory bowel disease.Scientific reports · 2021Article
- Relationship between clinical features and intestinal microbiota in Chinese patients with ulcerative colitis.World journal of gastroenterology · 2021Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Dysbiosis of intestinal microflora has been postulated in ulcerative colitis (UC), which is characterized by imbalance of mucosal tissue associated bacterial communities. However, the specific changes in mucosal microflora during different stages of UC are still unknown. The aim of the current study was to investigate the changes in mucosal tissue associated microbiota during acute exacerbations and remission stages of UC. The mucosal microbiota associated with colon biopsy of 12 patients suffering from UC (exacerbated stage) and the follow-up samples from the same patients (remission stage) as well as non-IBD subjects was studied using 16S rRNA gene-based sequencing and quantitative PCR. The total bacterial count in patients suffering from exacerbated phase of UC was observed to be two fold lower compared to that of the non-IBD subjects (p = 0.0049, Wilcox on matched-pairs signed rank tests). Bacterial genera including Stenotrophomonas, Parabacteroides, Elizabethkingia, Pseudomonas, Micrococcus, Ochrobactrum and Achromobacter were significantly higher in abundance during exacerbated phase of UC as compared to remission phase. The alterations in bacterial diversity with an increase in the abnormal microbial communities signify the extent of dysbiosis in mucosal microbiota in patients suffering from UC. Our study helps in identifying the specific genera dominating the microbiota during the disease and thus lays a basis for further investigation of the possible role of these bacteria in pathogenesis of UC.
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Registered trials
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