Evidence map›Paper›PMID 29796854›Full record

ReviewClinical & experimental metastasis2018

Breast cancer metastasis through the lympho-vascular system.

S David Nathanson, David Krag, Henry M Kuerer, Lisa A Newman, Markus Brown, Dontscho Kerjaschki, Ethel R Pereira, Timothy P Padera

Abstract readReview
PubMed Publisher
In one paragraph

Review in Clinical & experimental metastasis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Genomic spectra of lymphovascular invasion in breast cancer.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2025
    Article
  6. Article
  7. Article
  8. The potential of lenvatinib in breast cancer therapy.Medical oncology (Northwood, London, England) · 2024
    Review
  9. Review
  10. Article
  11. Cancer metastasis through the lymphatic versus blood vessels.Clinical & experimental metastasis · 2024
    Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 2 countries.

S David NathansonDepartment of Surgery, Division of Surgical Oncology, Henry Ford Cancer Institute, 2799 West Grand Boulevard, Detroit, MI, 48202, USA. dnathan1@hfhs.org.
David KragCollege of Medicine, University of Vermont, 89 Beaumont Ave, Burlington, VT, 05405, USA.
Henry M KuererDepartment of Breast Surgical Oncology, Division of Surgery, The University of Texas MD Anderson Cancer Center, 1400 Pressler St, Houston, TX, 77004, USA.
Lisa A NewmanInternational Center for the Study of Breast Cancer Subtypes, Henry Ford Health System, 2799 West Grand Blvd, Detroit, MI, 48202, USA.
Markus BrownGenentech, South San Francisco, CA, 94080, USA.
Dontscho KerjaschkiDepartment of Pathology, Medical University of Vienna, Vienna, Austria.
Ethel R PereiraEdwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital Cancer Center, MGH and Harvard Medical School, Boston, MA, 02114, USA.
Timothy P PaderaEdwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital Cancer Center, MGH and Harvard Medical School, Boston, MA, 02114, USA.
Harvard University · USHenry Ford Health System · USHenry Ford Hospital · USMassachusetts General Hospital · USMedical University of Vienna · ATThe University of Texas MD Anderson Cancer Center · USUniversity of Vermont · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer metastasizes through the lymphovascular system to the regional lymph nodes in the axilla and to both visceral and non-visceral sites. Renewed interest in the route by which tumor cells gain access to blood and lymphatic capillaries are the subject of research at mechanical, anatomic, pathologic, genetic, epidemiologic and molecular levels. Two papers presented at the 7th International Symposium on Cancer Metastasis in San Francisco showed tumor cells entering the systemic circulation through the sentinel lymph node. This information challenges the current paradigm where clinicians believe that access is gained through intra- and peri-tumoral blood vessels and that metastasis to axillary lymph nodes is an interesting epi-phenomenon. The sentinel lymph node era has changed the modern surgical approach to the axilla and the basis of this change is summarized in this paper. A new approach to the management of axillary metastases after systemic therapy relies on determining whether there is a complete pathologic response; if no tumor is found in the previously biopsied node, a complete axillary lymph node dissection may be avoided. African American women seem to inherit a trait from West African ancestors and tend to develop more lethal types of breast cancer. These tumors may have a molecular machinery that enhances their ability to metastasize to visceral sites and future research may unearth the mechanisms for this phenomenon.

Indexed as

Sentinel Lymph Node BiopsyBreast NeoplasmsFemaleHumansLymphatic MetastasisLymphatic SystemLymph NodesSentinel Lymph NodeAxillaBreast cancer sentinel lymph nodesMetastasisRacial disparitiesTargeted dissection

Identifiers

PMID29796854
OpenAlexW2803833798

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.