Evidence map›Paper›PMID 29796837›Full record

ReviewJournal of molecular neuroscience : MN2018

Transcriptional Regulation Involved in Fear Memory Reconsolidation.

Xu Wang, Min Li, Haitao Zhu, Yongju Yu, Yuanyuan Xu, Wenmo Zhang, Chen Bian

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of molecular neuroscience : MN, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Xu WangDepartment of Military Psychology, College of Psychology, Army Medical University, Chongqing, 400038, China.
Min LiDepartment of Military Psychology, College of Psychology, Army Medical University, Chongqing, 400038, China.
Haitao ZhuMedical Company, Troops 95848 of People's Liberation Army, Xiaogan, 432100, China.
Yongju YuDepartment of Military Psychology, College of Psychology, Army Medical University, Chongqing, 400038, China.
Yuanyuan XuDepartment of Military Psychology, College of Psychology, Army Medical University, Chongqing, 400038, China.
Wenmo ZhangDepartment of Fundamental, Army Logistical University of PLA, Chongqing, 401331, China.
Chen BianDepartment of Military Psychology, College of Psychology, Army Medical University, Chongqing, 400038, China. bc818@163.com.ORCID http://orcid.org/0000-0002-6366-1899
Army Medical University · CNPLA Army Service Academy · CN

Funding

Natural Science Foundation Project of CQ cstc2016jcyjA0587the National Science Foundation of China 31500896
6 · The paper itself

Abstract

Memory reconsolidation has been demonstrated to offer a potential target period during which the fear memories underlying fear disorders can be disrupted. Reconsolidation is a labile stage that consolidated memories re-enter after memories are reactivated. Reactivated memories, induced by cues related to traumatic events, are susceptible to strengthening and weakening. Gene transcription regulation and protein synthesis have been suggested to be required for fear memory reconsolidation. Investigating the transcriptional regulation mechanisms underlying reconsolidation may provide a therapeutic method for the treatment of fear disorders such as post-traumatic stress disorder (PTSD). However, the therapeutic effect of treating a fear disorder through interfering with reconsolidation is still contradictory. In this review, we summarize several transcription factors that have been linked to fear memory reconsolidation and propose that transcription factors, as well as related signaling pathways can serve as targets for fear memory interventions. Then, we discuss the application of pharmacological and behavioral interventions during reconsolidation that may or not efficiently treat fear disorders.

Indexed as

FearMemory ConsolidationTranscriptional ActivationAnimalsHumansStress Disorders, Post-TraumaticTranscription FactorsTranscription FactorsFear memoryPost-traumatic stress disorderReconsolidationTranscriptional factor

Identifiers

PMID29796837
OpenAlexW2804044926

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.