ArticleWorld journal of microbiology & biotechnology2018
Escherichia coli modular coculture system for resveratrol glucosides production.
Article in World journal of microbiology & biotechnology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 31 citations in OpenAlex.
- Cooperativity in microbial biotechnology: synthetic consortia as emerging metabolic engineering strategy for sustainable bioproduction.Frontiers in bioengineering and biotechnology · 2026Review
- A Novel Microbial Consortia Catalysis Strategy for the Production of Hydroxytyrosol from Tyrosine.International journal of molecular sciences · 2023Article
- Metabolic engineering and optimization of Escherichia coli co-culture for the de novo synthesis of genkwanin.Journal of industrial microbiology & biotechnology · 2023Article
- Artificial microbial consortia for bioproduction processes.Engineering in life sciences · 2023Review
- Bioproduction of eriodictyol by Escherichia coli engineered co-culture.World journal of microbiology & biotechnology · 2022Article
- Review
- Electrogenetic Signal Transmission and Propagation in Coculture to Guide Production of a Small Molecule, Tyrosine.ACS synthetic biology · 2022Article
- Modelling microbial communities: Harnessing consortia for biotechnological applications.Computational and structural biotechnology journal · 2021Review
- Metabolic modelling approaches for describing and engineering microbial communities.Computational and structural biotechnology journal · 2021Review
- De novo resveratrol production through modular engineering of an Escherichia coli-Saccharomyces cerevisiae co-culture.Microbial cell factories · 2020Article
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
Abstract
In bio-based fermentation, the overall bioprocess efficiency is significantly affected by the metabolic burden associated with the expression of complete biosynthetic pathway as well as precursor and cofactor generating enzymes into a single microbial cell. To attenuate such burden by compartmentalizing the enzyme expression, recently synthetic biologists have used coculture or poly-culture techniques for biomolecules synthesis. In this paper, coculture system of two metabolically engineered Escherichia coli populations were employed which comprises upstream module expressing two enzymes converting para-coumaric acid into resveratrol and the downstream module expressing glucosyltransferase to convert the resveratrol into its glucosidated forms; polydatin and resveratroloside. Upon optimization of the initial inoculum ratio of two E. coli populations, 92 mg resveratrol glucosides/L (236 µM) was produced i.e. achieving 84% bioconversion from 280 µM of p-coumaric acid in 60 h by 3 L fed batch fermentor. This is the report of applying coculture system to produce resveratrol glucosides by expressing the aglycone formation pathway and sugar dependent pathway into two different cells.
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