Evidence map›Paper›PMID 29796757›Full record

ArticleMycopathologia2018

Estrogen Receptor-α Correlates with Higher Fungal Cell Number in Oral Paracoccidioidomycosis in Women.

Clenivaldo Alves Caixeta, Marina Lara de Carli, Noé Vital Ribeiro Júnior, Felipe Fornias Sperandio, Suely Nonogaki, Denismar Alves Nogueira, Alessandro Antônio Costa Pereira, João Adolfo Costa Hanemann

Abstract read
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In one paragraph

Article in Mycopathologia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Polymorphism in the Promoter Region of theFrontiers in immunology · 2020
    Trial
  2. Article
  3. Telomeric assemblies ofbioRxiv : the preprint server for biology · 2025
    Article
  4. Article
  5. The Role of the Mycobiome in Women's Health.Journal of fungi (Basel, Switzerland) · 2023
    Review
  6. Review
  7. Updates inJournal of fungi (Basel, Switzerland) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Clenivaldo Alves CaixetaDepartment of Clinic and Surgery, School of Dentistry, Federal University of Alfenas, Rua Gabriel Monteiro da Silva 700, Alfenas, MG, 37130-001, Brazil. clenivaldodentista@yahoo.com.br.ORCID http://orcid.org/0000-0003-4943-5251
Marina Lara de CarliDepartment of Clinic and Surgery, School of Dentistry, Federal University of Alfenas, Rua Gabriel Monteiro da Silva 700, Alfenas, MG, 37130-001, Brazil.
Noé Vital Ribeiro JúniorDepartment of Clinic and Surgery, School of Dentistry, Federal University of Alfenas, Rua Gabriel Monteiro da Silva 700, Alfenas, MG, 37130-001, Brazil.
Felipe Fornias SperandioDepartment of Pathology and Parasitology, Institute of Biomedical Sciences, Federal University of Alfenas, Alfenas, Brazil.
Suely NonogakiInstitute of Pathology Adolfo Lutz, São Paulo, Brazil.
Denismar Alves NogueiraInstitute of Exact Sciences, Federal University of Alfenas, Alfenas, Brazil.
Alessandro Antônio Costa PereiraDepartment of Pathology and Parasitology, Institute of Biomedical Sciences, Federal University of Alfenas, Alfenas, Brazil.
João Adolfo Costa HanemannDepartment of Clinic and Surgery, School of Dentistry, Federal University of Alfenas, Rua Gabriel Monteiro da Silva 700, Alfenas, MG, 37130-001, Brazil.
Universidade Federal de Alfenas · BRInstituto Adolfo Lutz · BR

Funding

CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior) AUX PE PNPD 2386/2011
6 · The paper itself

Abstract

backgroundParacoccidioidomycosis is a neglected tropical fungal infection with great predilection for adult men, indicating the participation of female hormone estrogen in preventing paracoccidioidomycosis development in women. Estrogen has an immunologic effect leading to polarization toward the Th2 immune response, which favors the disease evolution.

objectivesTo evaluate estrogen and progesterone receptors in oral paracoccidioidomycosis lesions and to verify any association with tissue fungi counting in women and men.

methodsThirty-two cases of chronic oral paracoccidioidomycosis were included. Immunohistochemical analyses for anti-estrogen receptor-α, anti-progesterone receptor and anti-Paracoccidioides brasiliensis antibodies were performed. The differences between women and men and the relations among the immunomarkers for each gender were also evaluated.

resultsA significant positive correlation was observed between estrogen receptor-α and the amount of fungi in women. In addition, estrogen receptor-α was mildly expressed in the inflammatory cells of female patients, while progesterone receptor was expressed in both genders, with similar expression between women and men. Moreover, fungi counting revealed no differences between genders.

conclusionsEstrogen receptor-α was expressed only in women and showed a positive correlation with the amount of fungi in oral paracoccidioidomycosis, while progesterone receptor was observed in both genders and exhibited no correlation with estrogen receptor-α or fungi counting.

Indexed as

Colony Count, MicrobialAdultAgedEstrogen Receptor alphaFemaleHumansImmunohistochemistryMaleMiddle AgedMouth DiseasesParacoccidioidesParacoccidioidomycosisReceptors, ProgesteroneRetrospective StudiesYoung AdultEstrogen Receptor alphaReceptors, ProgesteroneImmune systemParacoccidioidomycosisReceptors, estrogenReceptors, progesterone

Identifiers

PMID29796757
OpenAlexW2803888202

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.