ArticleJournal of neuro-oncology2018
Impact of surgery and radiation therapy on spinal high-grade gliomas: a population-based study.
Article in Journal of neuro-oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prognostic Implication of Patient Age in H3K27M-Mutant Midline Gliomas.Frontiers in oncology · 2022Pooled it
- Spinal Metastasis from Supratentorial Glioblastoma: A Registry-Based Case Series and a Review of the Literature.Cancers · 2025Article
- Translational research of boron neutron capture therapy for spinal cord gliomas using rat model.Scientific reports · 2024Article
- Primary Intramedullary Spinal High-Grade Glioma: A Case Series with Review of Literature.South Asian journal of cancer · 2024Article
- Natural history of spinal cord metastasis from brain glioblastomas.Journal of neuro-oncology · 2023Article
- A comprehensive model including preoperative peripheral blood inflammatory markers for prediction of the prognosis of diffuse spinal cord astrocytoma following surgery.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2021Article
- Development and Validation of a Personalized Prognostic Prediction Model for Patients With Spinal Cord Astrocytoma.Frontiers in medicine · 2021Article
- Multifocal spinal glioblastoma and leptomeningeal carcinomatosis in an elderly male with hydrocephalus and myelopathy.Surgical neurology international · 2021Article
- Radiation-induced glioblastoma of the conus medullaris from radiation treatment of cervical cancer.BMJ case reports · 2020Article
- Clinicopathological characteristics and survival of spinal cord astrocytomas.Cancer medicine · 2020Article
- Adult primary high-grade spinal glioma: a nationwide analysis of current trends in treatment and outcomes.Journal of neuro-oncology · 2020Article
- Intracranial Metastases Originating From Pediatric Primary Spinal Cord Glioblastoma Multiforme: A Case Report and Literature Review.Frontiers in oncology · 2020Article
- Primary bulbo-medullary glioblastoma in a child: case report.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2019Article
- Adolescent and young adult glioma: systematic review of demographic, disease, and treatment influences on survival.Neuro-oncology advancesArticle
- The impact of prior radiation or chemotherapy on surgical outcomes in the treatment of spine metastases.Journal of craniovertebral junction & spineArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSpinal high-grade gliomas (S-HGGs) is an extremely rare entity in the literature, with only sporadic cases reported. We aim to characterize prognostic factors for post-treatment survival using the SEER database.
methodsWe examined all patients with gliomas located in the spinal cord. WHO-grade was first determined by site-specific factor-1 (WHO-grade), then supplemented by direct review of ICD-O-3 histology. Only grades 3 and 4 were included in this study. Multivariable Cox regression analysis was performed.
resultsA total of 158 high-grade spinal cord gliomas were included. Mean age at diagnosis was 36.88 years with 52.8% male. Median survival of all patients was 20 months. A stepwise Akaike information criterion was performed for multivariable Cox regression, with forced inclusion of surgery extent and postoperative radiation therapy (RT). The final model selection added tumor size in addition to these two variables. Tumor size was not related to survival in our study. The extend of surgery had no significant impact on survival of patients, whereas postoperative RT is associated with prolonged survival (HR = 0.55, CI [0.33, 0.93], p = 0.026).
conclusionS-HGGs are rare tumors with aggressive course of disease. We have found that overall median survival of S-HGGs is poor at 24 months, and no demographic or tumor-related factors have been confirmed. Extend of surgery is not associated with improved survival after adjusting for postoperative RT. Postoperative RT is the only factor in our study associated with prolonged survival in S-HGGs.
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