SynthesisAge and ageing2018
Cardiovascular risk factors and frailty in a cross-sectional study of older people: implications for prevention.
Synthesis in Age and ageing, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Cardiovascular Health, 2010 to 2020: A Systematic Review of a Decade of Research on Life's Simple 7.Journal of the American Heart Association · 2025Pooled it
- Overlap of Frailty and Depression and Its Association With Cardiovascular Disease: A Population-Based Study.Clinical Medicine Insights. Cardiology · 2026Article
- Prediction Model for Frailty in Middle-Aged and Older Adults with Cardiovascular Disease.Vascular health and risk management · 2026Article
- Chronic diseases and frailty transitions in community-dwelling older adults: evidence from a national longitudinal cohort study.BMC geriatrics · 2025Article
- Prevalence of Cardiovascular Risk Factors Among Adults in the European Union: A Systematic Review with Meta-Analysis.Journal of clinical medicine · 2025Review
- Predicting cardiovascular morbidity and mortality with SCORE2 (OP) and Framingham risk estimates in combination with indicators of biological ageing.Age and ageing · 2025Article
- Association of dietary health indices with frailty.BMC public health · 2025Article
- Utilizing multimodal approach to identify candidate pathways and biomarkers and predicting frailty syndrome in individuals from UK Biobank.GeroScience · 2024Article
- Frailty and risk of systemic atherosclerosis: A bidirectional Mendelian randomization study.PloS one · 2024Article
- Article
- Utility of SCORE2 risk algorithm for predicting life course accelerated frailty and physical function decline.Journal of cachexia, sarcopenia and muscle · 2023Article
- Physiological Systems in Promoting Frailty.Comprehensive Physiology · 2022Review
- Long sleep duration is associated with cognitive frailty among older community-dwelling adults: results from West China Health and Aging Trend study.BMC geriatrics · 2021Article
- Epigenetic age is associated with baseline and 3-year change in frailty in the Canadian Longitudinal Study on Aging.Clinical epigenetics · 2021Article
- Early-Life Socioeconomic Position and the Accumulation of Health-Related Deficits by Midlife in the 1958 British Birth Cohort Study.American journal of epidemiology · 2021Article
- Association between falls and cardiovascular diseases in the geriatric population.Archivos de cardiologia de Mexico · 2021Article
- Frailty Syndrome among oldest old Individuals, aged ≥80 years: Prevalence & Correlates.Journal of frailty, sarcopenia and falls · 2020Article
- Cardiovascular risk profile and frailty in Japanese outpatients: the Nambu Cohort Study.Hypertension research : official journal of the Japanese Society of Hypertension · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Objective: to examine the associations of cardiovascular disease (CVD) and cardiovascular risk factors with frailty. Design: a cross-sectional study. Setting: the Irish Longitudinal Study on Ageing (TILDA). Participants: frailty measures were obtained on 5,618 participants and a subset of 4,330 participants with no prior history of CVD. Exposures for observational study: cardiovascular risk factors were combined in three composite CVD risk scores (Systematic Coronary Risk Evaluation [SCORE], Ideal Cardiovascular Health [ICH] and Cardiovascular Health Metrics [CHM]). Main outcome measures: a frailty index (40-items) was used to screen for frailty. Methods: the associations of CVD risk factors with frailty were examined using logistic regression. Results: overall, 16.4% of participants had frailty (7.6% at 50-59 years to 42.5% at 80+ years), and the prevalence was higher in those with versus those without prior CVD (43.0% vs. 10.7%). Among those without prior CVD, mean levels of CVD risk factors were closely correlated with higher frailty index scores. Combined CVD risk factors, assessed using SCORE, were linearly and positively associated with frailty. Compared to low-to-moderate SCOREs, the odds ratio (OR) (95% confidence interval, CI) of frailty for those with very high risk was 3.18 (2.38-4.25). Conversely, ICH was linearly and inversely associated with frailty, with an OR for optimal health of 0.29 (0.21-0.40) compared with inadequate health. Conclusions: the concordant positive associations of SCORE and inverse associations of ICH and CHM with frailty highlight the potential importance of optimum levels of CVD risk factors for prevention of disability in frail older people.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.