ArticleJournal of endocrinology and diabetes2015
Autoantibodies in Human Diabetic Depression Inhibit Adult Neural Progenitor Cells
Article in Journal of endocrinology and diabetes, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed, 6 citations in OpenAlex.
- Immune Mechanisms in Neurodegenerative Disease: Role of Self-reactive Autoantibodies.Endocrinology, diabetes and metabolism journal · 2026Article
- Increased Plasma Serotonin 2A Receptor Autoantibodies Predicts Significant One-year Cognitive Decline in Middle-aged Adult Traumatic Brain Injury.Endocrinology, diabetes and metabolism journal · 2025Article
- Effects of a Serotonin Receptor Peptide on Behavioral Pattern Separation in Sham- vs. Mild Traumatic Brain Injured Rats.Endocrinology, diabetes and metabolism journal · 2024Article
- Neuroprotective Effects of a Serotonin Receptor Peptide Following ShamEndocrinology, diabetes and metabolism journal · 2023Article
- Schizophrenia Plasma Autoantibodies Promote 'Biased Agonism' at the 5-Hydroxytryptamine 2A Receptor: Neurotoxicity is Positively Modulated by Metabotropic Glutamate 2/3 Receptor Agonism.Endocrinology, diabetes and metabolism journal · 2019Article
- Diabetes Autoantibodies Mediate Neural- and Endothelial Cell- Inhibitory Effects Via 5-Hydroxytryptamine- 2 Receptor Coupled to Phospholipase C/Inositol Triphosphate/Ca2+ Pathway.Journal of endocrinology and diabetes · 2017Article
- Increased Neuronal Depolarization Evoked by Autoantibodies in Diabetic Obstructive Sleep Apnea: Role for Inflammatory Protease(s) in Generation of Neurotoxic Immunoglobulin Fragment.Journal of endocrinology and diabetes · 2017Article
- Toxic Immunoglobulin Light Chain Autoantibodies are Associated with a Cluster of Severe Complications in Older Adult Type 2 Diabetes.Journal of endocrinology and diabetes · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
aimDiabetic depression increases in association with microvascular complications. We tested a hypothesis that circulating autoantibodies having anti-endothelial and anti-neuronal properties increase in subsets of diabetes with co-morbid depression.
methodsProtein-A eluates from plasma of 20 diabetic depression patients and 30 age-matched controls were tested for effects on endothelial cell survival, neurite outgrowth in rat pheochromocytoma (PC12) cells, or process extension and survival in adult rat dentate gyrus neural progenitor cells. The protein-A eluates from depressed or non-depressed, diabetic patients were injected (via intracerebroventricular route) into mice and 7-10 days later behavioral tests (sucrose preference, and tail suspension tests) were conducted to determine whether the autoantibodies induced anhedonia or despair.
resultsDiabetic depression (n=20) autoantibodies caused a significant inhibition of PC12 cell neurite outgrowth (
conclusionThese data suggest that autoantibodies in a subset of older adult diabetic depression inhibit endothelial cell survival, and impair process extension and survival in adult dentate gyrus neural progenitor cells
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Registered trials
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