ArticleTransplantation direct2018
Biomarkers to Assess Right Heart Pressures in Recipients of a Heart Transplant: A Proof-of-Concept Study.
Article in Transplantation direct, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03152422 (Urinary Proteomics in Predicting Heart Transplantation Outcomes), which is not on this map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Urinary Proteomics in Predicting Heart Transplantation Outcomes
Who cites it
8 citing papers in PubMed, 9 citations in OpenAlex.
- Urinary proteomics combined with home blood pressure telemonitoring for health care reform trial-First progress report.Journal of clinical hypertension (Greenwich, Conn.) · 2023Trial
- [The importance of sex/gender for graft and patient survival].Innere Medizin (Heidelberg, Germany) · 2025Review
- OSTEO18, a novel urinary proteomic signature, associated with osteoporosis in heart transplant recipients.Heliyon · 2024Article
- Pre-dialysis care trajectory and post-dialysis survival and transplantation access in patients with end-stage kidney disease.Journal of nephrology · 2023Article
- Urinary proteomics combined with home blood pressure telemonitoring for health care reform trial: rational and protocol.Blood pressure · 2021Article
- Organ donation and transplantation: a multi-stakeholder call to action.Nature reviews. Nephrology · 2021Review
- Urinary Peptidomic Biomarker for Personalized Prevention and Treatment of Diastolic Left Ventricular Dysfunction.Proteomics. Clinical applications · 2019Review
- Urinary proteomic signatures associated with β-blockade and heart rate in heart transplant recipients.PloS one · 2018Article
Corrections and comments
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Authors and funding
17 authors at 3 institutions in 5 countries.
Funding
Abstract
backgroundThis proof-of-concept study investigated the feasibility of using biomarkers to monitor right heart pressures (RHP) in heart transplanted (HTx) patients.
methodsIn 298 patients, we measured 7.6 years post-HTx mean pressures in the right atrium (mRAP) and pulmonary artery (mPAP) and capillaries (mPCWP) along with plasma high-sensitivity troponin T (hsTnT), a marker of cardiomyocyte injury, and the multidimensional urinary classifiers HF1 and HF2, mainly consisting of dysregulated collagen fragments.
resultsIn multivariable models, mRAP and mPAP increased with hsTnT (per 1-SD, +0.91 and +1.26 mm Hg;
conclusionsCorrelating RHPs with noninvasive biomarkers in HTx patients is feasible. However, further refinement and validation of such biomarkers is required before their clinical application can be considered.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.