Evidence map›Paper›PMID 29796409›Full record

ArticleNPJ Parkinson's disease2018

Cognitive training for freezing of gait in Parkinson's disease: a randomized controlled trial.

Courtney C Walton, Loren Mowszowski, Moran Gilat, Julie M Hall, Claire O'Callaghan, Alana J Muller, Matthew Georgiades, Jennifer Y Y Szeto, Kaylena A Ehgoetz Martens, James M Shine and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ Parkinson's disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
26.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 92 citations in OpenAlex.

  1. Trial
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  3. A Randomized, Controlled Trial of Exercise for Parkinsonian Individuals With Freezing of Gait.Movement disorders : official journal of the Movement Disorder Society · 2020
    Trial
  4. Trial
  5. Article
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  7. Article
  8. Article
  9. Article
  10. An updated definition of freezing of gait.Nature reviews. Neurology · 2026
    Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 3 countries.

Courtney C Walton1Parkinson's Disease Research Clinic, Brain and Mind Centre, University of Sydney, Camperdown, NSW Australia.ORCID 0000-0003-0835-2310
Loren Mowszowski1Parkinson's Disease Research Clinic, Brain and Mind Centre, University of Sydney, Camperdown, NSW Australia.
Moran Gilat1Parkinson's Disease Research Clinic, Brain and Mind Centre, University of Sydney, Camperdown, NSW Australia.
Julie M Hall1Parkinson's Disease Research Clinic, Brain and Mind Centre, University of Sydney, Camperdown, NSW Australia.
Claire O'Callaghan1Parkinson's Disease Research Clinic, Brain and Mind Centre, University of Sydney, Camperdown, NSW Australia.
Alana J Muller1Parkinson's Disease Research Clinic, Brain and Mind Centre, University of Sydney, Camperdown, NSW Australia.
Matthew Georgiades1Parkinson's Disease Research Clinic, Brain and Mind Centre, University of Sydney, Camperdown, NSW Australia.
Jennifer Y Y Szeto1Parkinson's Disease Research Clinic, Brain and Mind Centre, University of Sydney, Camperdown, NSW Australia.
Kaylena A Ehgoetz Martens1Parkinson's Disease Research Clinic, Brain and Mind Centre, University of Sydney, Camperdown, NSW Australia.
James M Shine1Parkinson's Disease Research Clinic, Brain and Mind Centre, University of Sydney, Camperdown, NSW Australia.
Sharon L Naismith1Parkinson's Disease Research Clinic, Brain and Mind Centre, University of Sydney, Camperdown, NSW Australia.
Simon J G Lewis1Parkinson's Disease Research Clinic, Brain and Mind Centre, University of Sydney, Camperdown, NSW Australia.ORCID 0000-0002-4093-7071
The University of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The pathophysiological mechanism of freezing of gait (FoG) has been linked to executive dysfunction. Cognitive training (CT) is a non-pharmacological intervention which has been shown to improve executive functioning in Parkinson's disease (PD). This study aimed to explore whether targeted CT can reduce the severity of FoG in PD. Patients with PD who self-reported FoG and were free from dementia were randomly allocated to receive either a CT intervention or an active control. Both groups were clinician-facilitated and conducted twice-weekly for seven weeks. The primary outcome was percentage of time spent frozen during a Timed Up and Go task, assessed both on and off dopaminergic medications. Secondary outcomes included multiple neuropsychological and psychosocial measures. A full analysis was first conducted on all participants randomized, followed by a sample of interest including only those who had objective FoG at baseline, and completed the intervention. Sixty-five patients were randomized into the study. The sample of interest included 20 in the CT group and 18 in the active control group. The primary outcome of percentage time spent frozen during a gait task was significantly improved in the CT group compared to active controls in the on-state. There were no differences in the off-state. Patients who received CT also demonstrated improved processing speed and reduced daytime sleepiness compared to those in the active control. The findings suggest that CT can reduce the severity of FoG in the on-state, however replication in a larger sample is required.

Identifiers

PMID29796409
PMCPMC5959878
OpenAlexW2803613266

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.