Evidence map›Paper›PMID 29796338›Full record

ArticleGlobal advances in health and medicine2018

Tai Chi for Reducing Dual-task Gait Variability, a Potential Mediator of Fall Risk in Parkinson's Disease: A Pilot Randomized Controlled Trial.

Gloria Vergara-Diaz, Kamila Osypiuk, Jeffrey M Hausdorff, Paolo Bonato, Brian J Gow, Jose Gv Miranda, Lewis R Sudarsky, Daniel Tarsy, Michael D Fox, Paula Gardiner and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Global advances in health and medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 20 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 20 pooled it
10.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 20 syntheses or guidelines pooled it, 72 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 2 countries.

Gloria Vergara-DiazDepartment of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital, Charlestown, Massachusetts.
Kamila OsypiukOsher Center for Integrative Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts.
Jeffrey M HausdorffCenter for the Study of Movement, Cognition, and Mobility, Tel Aviv Sourasky Medical Center, Tel Aviv-Yafo, Israel.
Paolo BonatoDepartment of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital, Charlestown, Massachusetts.
Brian J GowOsher Center for Integrative Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts.
Jose Gv MirandaDepartment of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital, Charlestown, Massachusetts.
Lewis R SudarskyDepartment of Neurology, Brigham and Women's Hospital, Boston, Massachusetts.
Daniel TarsyDepartment of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts.
Michael D FoxDepartment of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts.
Paula GardinerDepartment of Family Medicine. Boston University School of Medicine, Boston, MA.
Cathi A ThomasDepartment of Neurology, Boston University Medical Campus, Boston, MA.
Eric A MacklinMassachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Peter M WayneOsher Center for Integrative Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts.
Harvard University · USBrigham and Women's Hospital · USBeth Israel Deaconess Medical Center · USBoston Medical Center · USBoston University · USMassachusetts General Hospital · USRush University Medical Center · USSpaulding Rehabilitation Hospital · US

Funding

Mentoring and research in mind-body and integrative therapiesK24AT009282 · NCCIH · BRIGHAM AND WOMEN'S HOSPITAL · PI WAYNE, PETER MICHAEL · 2017 to 2021
$834k
NCCIH NIH HHS K24 AT009282
6 · The paper itself

Abstract

objectivesTo assess the feasibility and inform design features of a fully powered randomized controlled trial (RCT) evaluating the effects of Tai Chi (TC) in Parkinson's disease (PD) and to select outcomes most responsive to TC assessed during off-medication states.

designTwo-arm, wait-list controlled RCT. SETTINGS: Tertiary care hospital. SUBJECTS: Thirty-two subjects aged 40-75 diagnosed with idiopathic PD within 10 years.

interventionsSix-month TC intervention added to usual care (UC) versus UC alone. OUTCOME MEASURES: Primary outcomes were feasibility-related (recruitment rate, adherence, and compliance). Change in dual-task (DT) gait stride-time variability (STV) from baseline to 6 months was defined, a priori, as the clinical outcome measure of primary interest. Other outcomes included: PD motor symptom progression (Unified Parkinson's Disease Rating Scale [UPDRS]), PD-related quality of life (PDQ-39), executive function (Trail Making Test), balance confidence (Activity-Specific Balance Confidence Scale, ABC), and Timed Up and Go test (TUG). All clinical assessments were made in the off-state for PD medications.

resultsThirty-two subjects were enrolled into 3 sequential cohorts over 417 days at an average rate of 0.08 subjects per day. Seventy-five percent (12/16) in the TC group vs 94% (15/16) in the UC group completed the primary 6-month follow-up assessment. Mean TC exposure hours overall: 52. No AEs occurred during or as a direct result of TC exercise. Statistically nonsignificant improvements were observed in the TC group at 6 months in DT gait STV (TC [20.1%] vs UC [-0.1%] group [effect size 0.49;

conclusionsConducting an RCT of TC for PD is feasible, though measures to improve recruitment and adherence rates are needed. DT gait STV is a sensitive and logical outcome for evaluating the combined cognitive-motor effects of TC in PD.

Indexed as

dual-task performancefeasibilitygait analysisParkinson’s diseaserandomized trialTai Chi

Identifiers

PMID29796338
PMCPMC5960860
OpenAlexW2803823834

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.