Evidence map›Paper›PMID 29796310›Full record

ArticleNPJ vaccines2018

Immune system correlates of extensive limb swelling in response to conjugated pneumococcal vaccination.

Mike Recher, Julia R Hirsiger, Marc B Bigler, Martin Iff, Barbara Lemaître, Kathrin Scherer, Peter Häusermann, Claire-Anne Siegrist, Christoph T Berger

Open access · goldAbstract readCase Reports
In one paragraph

Article in NPJ vaccines, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. SARS-CoV-2 Vaccines and the Skin.Actas dermo-sifiliograficas · 2021
    Review
  4. Vaccine-Induced CD8Frontiers in immunology · 2020
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Mike Recher1Immunodeficiency Clinic and Laboratory, Medical Outpatient Unit, Department Internal Medicine and Department Biomedicine, University Basel Hospital, Basel, Switzerland.
Julia R Hirsiger2Translational Immunology, Department of Biomedicine, University Basel Hospital, Basel, Switzerland.
Marc B Bigler2Translational Immunology, Department of Biomedicine, University Basel Hospital, Basel, Switzerland.
Martin IffInternal Medicine Praxis, Reinach, Switzerland.
Barbara Lemaître4Center for Vaccinology, Geneva University Hospitals, Geneva, Switzerland.
Kathrin Scherer5Allergy Unit, Department of Dermatology, University Basel Hospital, Basel, Switzerland.ORCID 0000-0002-5235-2556
Peter Häusermann6Department of Dermatology, University Basel Hospital, Basel, Switzerland.
Claire-Anne Siegrist4Center for Vaccinology, Geneva University Hospitals, Geneva, Switzerland.
Christoph T Berger2Translational Immunology, Department of Biomedicine, University Basel Hospital, Basel, Switzerland.ORCID 0000-0002-1730-8824
University Hospital of Basel · CHUniversity Hospital of Geneva · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pneumococcal conjugate vaccine (PCV) is recommended for adults with chronic disease. Extensive limb swelling (ELS) is an acute vigorous local inflammatory reaction following vaccination. Predisposing immune system correlates and the influence of ELS on vaccine responses are not known. Here, we report a case of a 67-year-old woman with a history of multiple pneumonias who had a detailed immunological work-up pre-vaccination because of suspected immunodeficiency. Four days following a first vaccination with PCV13 she developed ELS-mimicking erysipelas. Treatment with 20 mg cortisone completely alleviated symptoms within 2 days. Skin biopsy showed a dense dermal and subdermal infiltration dominated by CD4

Identifiers

PMID29796310
PMCPMC5959910
OpenAlexW2805757722

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.