Evidence map›Paper›PMID 29796309›Full record

ArticleCell death discovery2018

Deubiquitinase function of A20 maintains and repairs endothelial barrier after lung vascular injury.

Dheeraj Soni, Dong-Mei Wang, Sushil C Regmi, Manish Mittal, Stephen M Vogel, Dirk Schlüter, Chinnaswamy Tiruppathi

Open access · goldAbstract read
In one paragraph

Article in Cell death discovery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 28 citations in OpenAlex.

  1. Deubiquitinases as Regulators and Therapeutic Targets in Vascular Diseases.International journal of molecular sciences · 2026
    Review
  2. Review
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  11. A20 Is Increased in Fetal Lung in a Sheep LPS Model of Chorioamnionitis.Oxidative medicine and cellular longevity · 2022
    Article
  12. Article
  13. Article
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  15. Article
  16. Review
  17. The Role of Deubiquitinases in Vascular Diseases.Journal of cardiovascular translational research · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Dheeraj Soni *1Department of Pharmacology and Center for Lung and Vascular Biology, College of Medicine, University of Illinois, Chicago, IL USA.ORCID 0000-0002-5555-2051
Dong-Mei Wang *1Department of Pharmacology and Center for Lung and Vascular Biology, College of Medicine, University of Illinois, Chicago, IL USA.
Sushil C Regmi1Department of Pharmacology and Center for Lung and Vascular Biology, College of Medicine, University of Illinois, Chicago, IL USA.
Manish Mittal1Department of Pharmacology and Center for Lung and Vascular Biology, College of Medicine, University of Illinois, Chicago, IL USA.
Stephen M Vogel1Department of Pharmacology and Center for Lung and Vascular Biology, College of Medicine, University of Illinois, Chicago, IL USA.
Dirk Schlüter2Institute of Medical Microbiology and Hospital Hygiene, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.
Chinnaswamy Tiruppathi1Department of Pharmacology and Center for Lung and Vascular Biology, College of Medicine, University of Illinois, Chicago, IL USA.
University of Illinois Urbana-Champaign · USUniversity Hospital Magdeburg · DE

Funding

Endothelial Cell Deubiquitinase A20 Signals Repair of Lung Vascular InjuryR01HL128359 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI TIRUPPATHI, CHINNASWAMY · 2015 to 2018
$1.6M
TRPM2 mediates neutrophil transendothelial migration and inflammationR01HL122157 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI TIRUPPATHI, CHINNASWAMY · 2015 to 2018
$1.6M
Endothelial TAK1 Signaling and Resolution of Pulmonary Edema in SepsisR01GM117028 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI TIRUPPATHI, CHINNASWAMY · 2016 to 2019
$1.3M
NHLBI NIH HHS R01 HL122157NHLBI NIH HHS R01 HL128359NIGMS NIH HHS R01 GM117028
6 · The paper itself

Abstract

Vascular endothelial cadherin (VE-cad) expression at endothelial adherens junctions (AJs) regulates vascular homeostasis. Here we show that endothelial A20 is required for VE-cad expression at AJs to maintain and repair the injured endothelial barrier. In endothelial cell (EC)-restricted

Identifiers

PMID29796309
PMCPMC5955943
OpenAlexW2803352502

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.