Evidence map›Paper›PMID 29796293›Full record

ArticlePilot and feasibility studies2018

Intensive therapy after botulinum toxin in adults with spasticity after stroke versus botulinum toxin alone or therapy alone: a pilot, feasibility randomized trial.

Natasha A Lannin, Louise Ada, Tamina Levy, Coralie English, Julie Ratcliffe, Doungkamol Sindhusake, Maria Crotty

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pilot and feasibility studies, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 7 institutions in 1 country.

Natasha A Lannin1School of Allied Health (Occupational Therapy), La Trobe University, Melbourne, Australia.
Louise Ada3Physiotherapy, The University of Sydney, Sydney, Australia.
Tamina LevyRepatriation General Hospital, Flinders University, Adelaide, Australia.
Coralie English5School of Health Sciences and Priority Research Centre for Stroke and Brain Injury, The University of Newcastle, Newcastle, Australia.
Julie Ratcliffe6Institute for Choice, UniSA Business School, University of South Australia, Adelaide, Australia.
Doungkamol SindhusakeClinical Excellence Commission New South Wales, Sydney, Australia.
Maria CrottyRepatriation General Hospital; Flinders University, Adelaide, Australia.
Flinders University · AULa Trobe University · AUMental Health Commission · AURepatriation General Hospital · AUUniversity of Newcastle Australia · AUUniversity of South Australia · AUUniversity of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBotulinum toxin-A is provided for adults with post-stroke spasticity. Following injection, there is a variation in the rehabilitation therapy type and amount provided. The purpose of this study was to determine if it is feasible to add intensive therapy to botulinum toxin-A injections for adults with spasticity and whether it is likely to be beneficial.

methodsRandomized trial with concealed allocation, assessor blinding, and intention to treat analysis. Thirty-seven adults (

resultsOverall recruitment fraction for the trial was 37% (eligibility fraction 39%, enrolment fraction 95%). The 26 participants allocated to receive intensive rehabilitation attended 97% of clinic-based sessions (mean 11 ± 2 h) and an averaged 58% (mean 52 ± 32 h) of prescribed 90 h of independent practice. There were no study-related adverse events reported. Although participants in all groups increased their goal attainment, there were no between-group differences for this or other outcomes at week 8 or 12.

conclusionProviding intensive therapy following botulinum toxin-A is feasible for adults with neurological spasticity. The study methods are appropriate for a future trial. A future trial would require 134 participants to detect a between-group difference of 7 points on Goal Attainment Scale

trial registrationACTRN12612000091808. Registered 18/01/2012, retrospective.

Indexed as

Botulinum toxinsMuscle spasticityOccupational therapyPhysical therapyRehabilitationStroke

Identifiers

PMID29796293
PMCPMC5963180
OpenAlexW2807195360

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.