Evidence map›Paper›PMID 29796275›Full record

ArticleRespirology case reports2018

Eosinophilia as a treatable trait in three patients with asthma and COPD.

James Michael Ramsahai, Jodie Simpson, Peter Wark

Abstract readCase Reports
In one paragraph

Article in Respirology case reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Tezepelumab for asthma with current or previous smoking habit: Case series.The journal of allergy and clinical immunology. Global · 2025
    Article
  4. Asthma-COPD overlap: current understanding and the utility of experimental models.European respiratory review : an official journal of the European Respiratory Society · 2021
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

James Michael RamsahaiHunter Medical Research Institute University of Newcastle New Lambton NSW Australia.ORCID 0000-0002-5164-9374
Jodie SimpsonHunter Medical Research Institute University of Newcastle New Lambton NSW Australia.
Peter WarkHunter Medical Research Institute University of Newcastle New Lambton NSW Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The combination of asthma and chronic obstructive pulmonary disease (COPD) in an individual can present significant challenges to achieving satisfactory outcomes. More recently, the concepts of precision medicine and treatable traits have arisen as promising tools to improve care for this group. In this series, we present three cases of patients with features of both asthma and COPD in addition to peripheral blood eosinophilia. The novel implementation of personalized management of the individual based on this treatable trait (eosinophilia) resulted in significant benefits. These benefits included improvement in symptoms, lung function, and a marked decline in critical care admissions and exacerbation rates.

Indexed as

ACOSasthmaCOPDeosinophiliatreatable trait

Identifiers

PMID29796275
PMCPMC5961508

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.