ArticleSAGE open medicine2018
Physical activity mediates the association between personality and biomarkers of inflammation.
Article in SAGE open medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Personality nuances and inflammation: A coordinated analysis of six samples.Psychoneuroendocrinology · 2026Pooled it
- Personality and mortality risk: A systematic review and meta-analysis of longitudinal data.Journal of personality and social psychology · 2026Pooled it
- The Big Five personality traits and allostatic load in middle to older adulthood: A systematic review and meta-analysis.Neuroscience and biobehavioral reviews · 2023Pooled it
- Reporting heterogeneity in the associations between personality and health problems: Anchoring self-reports with health vignettes.Journal of health psychology · 2025Article
- The association of Conscientiousness and Neuroticism on BMI and health behaviours: exploring the impact of Healthy Neuroticism.Frontiers in psychology · 2025Article
- Personality and Psychoneuroimmunology: A Systems Biology Perspective.Methods in molecular biology (Clifton, N.J.) · 2025Review
- The Association Between Personality Traits and Health-Related Quality of Life and the Mediating Role of Smoking: Nationwide Cross-Sectional Study.JMIR public health and surveillance · 2024Article
- Personality and Cognition: The Mediating Role of Inflammatory Markers.The journals of gerontology. Series B, Psychological sciences and social sciences · 2024Article
- Network analysis of the associations between personality traits, cognitive functioning, and inflammatory markers in elderly individuals without dementia.Frontiers in aging neuroscience · 2023Article
- Prospective self- and informant-personality associations with inflammation, health behaviors, and health indicators.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2022Article
- Emotion regulation difficulties, perceived parenting and personality as predictors of health-risk behaviours among adolescents.Current psychology (New Brunswick, N.J.) · 2022Article
- Neuroticism is positively associated with leptin/adiponectin ratio, leptin and IL-6 in young adults.Scientific reports · 2021Article
- Personality pathways to mortality: Interleukin-6 links conscientiousness to mortality risk.Brain, behavior, and immunity · 2021Article
- Personality traits and physical functioning: a cross-sectional multimethod facet-level analysis.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2020Article
- Is Healthy Neuroticism Associated with Health Behaviors? A Coordinated Integrative Data Analysis.Collabra. Psychology · 2020Article
- Is Healthy Neuroticism Associated with Longevity? A Coordinated Integrative Data Analysis.Collabra. Psychology · 2020Article
- Associations of Personality Traits With Chronic Low-Grade Inflammation in a Swiss Community Sample.Frontiers in psychiatry · 2019Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
objectivesThe current study investigated whether personality traits and facets were associated with interleukin-6, C-reactive protein, and fibrinogen, and whether physical activity mediated the relationship between personality and biomarkers of inflammation.
methodsPersonality was assessed in the Midlife Development in the United States study using the Multi-Dimensional Personality Questionnaire and Midlife Development Inventory personality scale. Data were included from 960 participants (mean age = 57.86 years, standard deviation = 11.46). Personality was assessed from 2004 to 2009. Serum levels of interleukin-6, fibrinogen, and C-reactive protein were assessed in 2005-2009 as part of the Midlife Development in the United States biomarkers subproject.
resultsLower neuroticism was associated with elevated interleukin-6, and achievement was associated with lower fibrinogen. Higher physical activity was associated with lower interleukin-6 and C-reactive protein. Mediation models suggested that physical activity mediated the associations between achievement and both interleukin-6 and C-reactive protein. DISCUSSION: Physical activity is an important factor in the Health Behavior Model of personality and explains some of the associations between personality and inflammation. These findings contribute to the fields of aging and health by linking individual difference factors to markers of inflammation, and showing that these processes may function partially through specific behaviors, in this case physical activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.