Evidence map›Paper›PMID 29796158›Full record

ArticleOncotarget2018

SRC/ABL inhibition disrupts CRLF2-driven signaling to induce cell death in B-cell acute lymphoblastic leukemia.

Jolanda Sarno, Angela M Savino, Chiara Buracchi, Chiara Palmi, Stefania Pinto, Cristina Bugarin, Astraea Jager, Silvia Bresolin, Ruth C Barber, Daniela Silvestri and 7 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 4 countries.

Jolanda SarnoDepartment of Pediatrics, Bass Center for Childhood Cancer and Blood Disorders, Stanford University, Stanford, CA, USA.
Angela M SavinoCancer Research Center, Sheba Medical Center, Ramat Gan, Israel.
Chiara BuracchiM. Tettamanti Research Center, Pediatric Clinic, University of Milano Bicocca, Monza, Italy.
Chiara PalmiM. Tettamanti Research Center, Pediatric Clinic, University of Milano Bicocca, Monza, Italy.
Stefania PintoM. Tettamanti Research Center, Pediatric Clinic, University of Milano Bicocca, Monza, Italy.
Cristina BugarinM. Tettamanti Research Center, Pediatric Clinic, University of Milano Bicocca, Monza, Italy.
Astraea JagerDepartment of Pediatrics, Bass Center for Childhood Cancer and Blood Disorders, Stanford University, Stanford, CA, USA.
Silvia BresolinLaboratory of Onco-Hematology, Department of Women's and Children's Health, University of Padova, Padova, Italy.
Ruth C BarberLeicester Drug Discovery & Diagnostic Centre, University of Leicester, Leicester, United Kingdom.
Daniela SilvestriBiostatistics and Clinic Epidemiology Center, University of Milano Bicocca, Monza, Italy.
Shai IsraeliCancer Research Center, Sheba Medical Center, Ramat Gan, Israel.
Martin J S DyerErnest and Helen Scott Haematological Research Institute, University of Leicester, Leicester, United Kingdom.
Giovanni CazzanigaM. Tettamanti Research Center, Pediatric Clinic, University of Milano Bicocca, Monza, Italy.
Garry P NolanBaxter Laboratory in Stem Cell Biology, Department of Microbiology and Immunology, Stanford University, Stanford, CA, USA.
Andrea BiondiM. Tettamanti Research Center, Pediatric Clinic, University of Milano Bicocca, Monza, Italy.
Kara L DavisDepartment of Pediatrics, Bass Center for Childhood Cancer and Blood Disorders, Stanford University, Stanford, CA, USA.
Giuseppe GaipaM. Tettamanti Research Center, Pediatric Clinic, University of Milano Bicocca, Monza, Italy.
University of Milano-Bicocca · ITStanford University · USSheba Medical Center · ILUniversity of Leicester · GBUniversity of Padua · IT

Funding

Medical Research Council MC_U132670597
6 · The paper itself

Abstract

Children with B-cell precursor acute lymphoblastic leukemia (BCP-ALL) overexpressing the

Indexed as

acute lymphoblastic leukemiacell signalingmass cytometryminimal residual diseasesignal transduction inhibitors

Identifiers

PMID29796158
PMCPMC5955419
OpenAlexW2800022392

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.