ArticleDiabetology & metabolic syndrome2018
Assessing the added predictive ability of a metabolic syndrome severity score in predicting incident cardiovascular disease and type 2 diabetes: the Atherosclerosis Risk in Communities Study and Jackson Heart Study.
Article in Diabetology & metabolic syndrome, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 33 citations in OpenAlex.
- Impact of Setmelanotide on Metabolic Syndrome Risk in Patients With Bardet-Biedl Syndrome.The Journal of clinical endocrinology and metabolism · 2025Trial
- Confirmatory-factor-analysis-derived metabolic syndrome risk score: development, validation, and clinical utility in dual adolescent populations.Pediatric research · 2026Article
- Impact of a combined lower carbohydrate and Mediterranean diet on metabolic syndrome severity: protocol for a randomised controlled trial.The British journal of nutrition · 2026Article
- Nonlinear Association Between Metabolic Syndrome Severity and Advanced Fibrosis in Metabolic Dysfunction-Associated Steatotic Liver Disease.Gastro hep advances · 2026Article
- Differences of Sedentary Behavior, Physical Activity, and Metabolic Syndrome Severity Among Metabolic Syndrome Clusters.American journal of lifestyle medicine · 2025Article
- Exploratory analysis of the variable response to an intensive lifestyle change program for metabolic syndrome.BMC primary care · 2024Article
- Association between Atherogenic Dyslipidemia and Subclinical Myocardial Injury in the General Population.Journal of clinical medicine · 2024Article
- Harnessing Metabolic Indices as a Predictive Tool for Cardiovascular Disease in a Korean Population without Known Major Cardiovascular Event.Diabetes & metabolism journal · 2024Article
- The impact of metabolic syndrome severity on racial and ethnic disparities in Metabolic Dysfunction-Associated Steatotic Liver Disease.PloS one · 2024Article
- Association between metabolic syndrome severity score and cardiovascular disease: results from a longitudinal cohort study on Chinese adults.Frontiers in endocrinology · 2024Article
- Trajectory patterns of metabolic syndrome severity score and risk of type 2 diabetes.Journal of translational medicine · 2023Article
- Independent association between age- and sex-specific metabolic syndrome severity score and cardiovascular disease and mortality.Scientific reports · 2023Article
- Derivation and validation of sex-specific continuous metabolic syndrome scores for the Mexican adult population.Scientific reports · 2022Article
- Observational
- Metabolic Syndrome Severity Predicts Mortality in Nonalcoholic Fatty Liver Disease.Gastro hep advances · 2022Article
- Metabolic Syndrome Is Associated With Poor Cognition: A Population-Based Study of 70-Year-Old Adults Without Dementia.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- The association of sleep duration and metabolic syndrome in the Bandare-Kong cohort study, a cross-sectional survey (finding from PERSIAN cohort study).Diabetology & metabolic syndrome · 2021Article
- Metabolic Syndrome Severity Score for Predicting Cardiovascular Events: A Nationwide Population-Based Study from Korea.Diabetes & metabolism journal · 2021Article
- Contribution of Components of Metabolic Syndrome to Cognitive Performance in Middle-Aged Adults.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2021Article
- TCF7L2 polymorphisms, nut consumption, and the risk of metabolic syndrome: a prospective population based study.Nutrition & metabolism · 2021Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe severity of the metabolic syndrome (MetS) predicts future coronary heart disease (CHD) and diabetes independent of the individual MetS components. Our aim was to evaluate whether MetS severity conferred additional discrimination to existing scoring systems for cardiovascular disease (CVD) and diabetes risk.
methodsWe assessed Cox proportional hazard models of CHD- and diabetes risk among 13,141 participants of the Atherosclerosis Risk in Communities Study and the Jackson Heart Study, using the Framingham Risk Calculator, the American Heart Association's Atherosclerotic CVD calculator, the American Diabetes Association diabetes risk score and an additional diabetes risk score derived from ARIC data. We then added a MetS-severity Z-score to these models and assessed for added risk discrimination by assessing Akaike information criterion, c-statistic, integrated discrimination improvement (IDI) and continuous net reclassification improvement (NRI).
resultsThe MetS severity score appears to add to the predictive ability of individual CHD and diabetes risk scores. Using the IDI, MetS improved risk prediction for diabetes but not CHD risk. In all 4 scoring systems, MetS severity had a significant non-event NRI, improving the ability to exclude individuals without events. Assessing interactions between risk scores and MetS severity revealed that MetS severity was more highly associated with disease risk among those in the lowest quintiles of risk score, suggesting that MetS was particularly able to identify risk among individuals judged to be of low risk by existing algorithms.
conclusionsMets severity improved prediction of diabetes more so than CHD. Incorporation of multiple risk predictors into electronic health records may help in better identifying those at high disease risk, who can then be placed earlier on preventative therapy.
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