ArticleNeural plasticity2018
Changes in Resting-State Connectivity following Melody-Based Therapy in a Patient with Aphasia.
Article in Neural plasticity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 17 citations in OpenAlex.
- Can Phonotherapy Serve as an Adjunct Treatment for Acute and Chronic Stroke? A Preliminary Report.Healthcare (Basel, Switzerland) · 2026Article
- Systematic review and meta-analysis reveal positive therapeutic effects of music in brain damage rehabilitation.Frontiers in integrative neuroscience · 2026Review
- Test-retest reliability of edge-level resting-state functional connectivity in people with aphasia.Neuroimage. Reports · 2025Article
- The role of musical aspects of language in human cognition.Frontiers in psychology · 2025Review
- Music Therapy in Global Aphasia: A Case Report.Medicines (Basel, Switzerland) · 2023Article
- Simultaneous Normalization and Compensatory Changes in Right Hemisphere Connectivity during Aphasia Therapy.Brain sciences · 2021Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Melody-based treatments for patients with aphasia rely on the notion of preserved musical abilities in the RH, following left hemisphere damage. However, despite evidence for their effectiveness, the role of the RH is still an open question. We measured changes in resting-state functional connectivity following melody-based intervention, to identify lateralization of treatment-related changes. A patient with aphasia due to left frontal and temporal hemorrhages following traumatic brain injuries (TBI) more than three years earlier received 48 sessions of melody-based intervention. Behavioral measures improved and were maintained at the 8-week posttreatment follow-up. Resting-state fMRI data collected before and after treatment showed an increase in connectivity between motor speech control areas (bilateral supplementary motor areas and insulae) and RH language areas (inferior frontal gyrus pars triangularis and pars opercularis). This change, which was specific for the RH, was greater than changes in a baseline interval measured before treatment. No changes in RH connectivity were found in a matched control TBI patient scanned at the same intervals. These results are compatible with a compensatory role for RH language areas following melody-based intervention. They further suggest that this therapy intervenes at the level of the interface between language areas and speech motor control areas necessary for language production.
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Registered trials
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