ArticleScience advances2018
Graphene biointerfaces for optical stimulation of cells.
Article in Science advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 96 citations in OpenAlex.
- Intracellular sensing with transparent graphene-nanotube electrodes.2d materials · 2026Article
- Cardiac action potential generation mechanisms via an intramembrane photoswitch. A simulation study.Biophysical journal · 2025Article
- Graphene-polymer nanofibers enable optically induced electrical responses in stem cell-derived electrically excitable cells and brain organoids.Biomaterials · 2025Article
- Non-genetic neuromodulation with graphene optoelectronic actuators for disease models, stem cell maturation, and biohybrid robotics.Nature communications · 2025Article
- Perspective on Nano-Enabled Photostimulation Biointerfaces.ACS nano · 2025Review
- Electrically Active Biomaterials for Stimulation and Regeneration in Tissue Engineering.Journal of biomedical materials research. Part A · 2025Review
- Enhancing the Maturation of Human Pluripotent Stem Cell-Derived Cardiomyocytes with an n-Type Organic Semiconductor Coating.ACS applied materials & interfaces · 2024Article
- Advances in Biointegrated Wearable and Implantable Optoelectronic Devices for Cardiac Healthcare.Cyborg and bionic systems (Washington, D.C.) · 2024Review
- Nongenetic Optical Modulation of Pluripotent Stem Cells Derived Cardiomyocytes Function in the Red Spectral Range.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Skeletal muscle cells opto-stimulation by intramembrane molecular transducers.Communications biology · 2023Article
- Soft, bioresorbable, transparent microelectrode arrays for multimodal spatiotemporal mapping and modulation of cardiac physiology.Science advances · 2023Article
- Graphene Biointerface for Cardiac Arrhythmia Diagnosis and Treatment.Advanced materials (Deerfield Beach, Fla.) · 2023Article
- Light-triggered cardiac microphysiological model.APL bioengineering · 2023Article
- Bioresorbable thin-film silicon diodes for the optoelectronic excitation and inhibition of neural activities.Nature biomedical engineering · 2023Article
- Optical modulation of excitation-contraction coupling in human-induced pluripotent stem cell-derived cardiomyocytes.iScience · 2023Article
- The mechanical, optical, and thermal properties of graphene influencing its pre-clinical use in treating neurological diseases.Frontiers in neuroscience · 2023Review
- Graphene-based cardiac sensors and actuators.Frontiers in bioengineering and biotechnology · 2023Review
- Bio-hybrid electronic and photonic devices.Experimental biology and medicine (Maywood, N.J.) · 2022Review
- Computational Analysis of Cardiac Contractile Function.Current cardiology reports · 2022Review
- G-Optrode Bio-Interfaces for Non-Invasive Optical Cell Stimulation: Design and Evaluation.Biosensors · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 4 countries.
Funding
Abstract
Noninvasive stimulation of cells is crucial for the accurate examination and control of their function both at the cellular and the system levels. To address this need, we present a pioneering optical stimulation platform that does not require genetic modification of cells but instead capitalizes on unique optoelectronic properties of graphene, including its ability to efficiently convert light into electricity. We report the first studies of optical stimulation of cardiomyocytes via graphene-based biointerfaces (G-biointerfaces) in substrate-based and dispersible configurations. The efficiency of stimulation via G-biointerfaces is independent of light wavelength but can be tuned by changing the light intensity. We demonstrate that an all-optical evaluation of use-dependent drug effects in vitro can be enabled using substrate-based G-biointerfaces. Furthermore, using dispersible G-biointerfaces in vivo, we perform optical modulation of the heart activity in zebrafish embryos. Our discovery is expected to empower numerous fundamental and translational biomedical studies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.