ArticleNeurophotonics2018
Using a simulation approach to optimize time-domain diffuse correlation spectroscopy measurement on human head.
Article in Neurophotonics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- Depth-sensitive cerebral blood flow and low-frequency oscillations for consciousness assessment using time-domain diffuse correlation spectroscopy.Neurophotonics · 2026Article
- Fast time-domain diffuse correlation spectroscopy with superconducting nanowire single-photon detector: system validation and in vivo results.Scientific reports · 2023Article
- First-in-clinical application of a time-gated diffuse correlation spectroscopy system at 1064 nm using superconducting nanowire single photon detectors in a neuro intensive care unit.Biomedical optics express · 2022Article
- Functional Time Domain Diffuse Correlation Spectroscopy.Frontiers in neuroscience · 2022Article
- Performance assessment of laser sources for time-domain diffuse correlation spectroscopy.Biomedical optics express · 2021Article
- Optimization of time domain diffuse correlation spectroscopy parameters for measuring brain blood flow.Neurophotonics · 2021Article
- Direct assessment of extracerebral signal contamination on optical measurements of cerebral blood flow, oxygenation, and metabolism.Neurophotonics · 2020Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Time-domain diffuse correlation spectroscopy (TD-DCS) has been recently proposed to improve detection of deep blood flow dynamics in a biological tissue, such as human brain. To obtain a high sensitive measurement, several experimental parameters such as the source-detector (SD) distance, gate opening time, and width need to be considered and optimized. We use a simulation approach to optimize these parameters based on Monte Carlo computations using a realistic human head model. Two cortical regions are investigated including the frontal and temporal lobes. SD distance ranging from 0 to 45 mm, gate opening time from 400 to 1000 ps, and gate width from 50 to 3000 ps are considered. The goal is to find out the optimal combinations of these parameters by which the higher contrast measurement on the cortical dynamics can be achieved. The simulations show that with an acceptable input power of light, the combinations of SD distance ranging from 0 to 15 mm, gate opening time at 700 to 800 ps, and gate width of 800 ps are optimal for achieving higher contrast measurement on the cortical dynamics. The simulation approach and results are helpful for the optimization of TD-DCS experimental design focused on brain functional detection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.