ArticleACS medicinal chemistry letters2018
BMS-986163, a Negative Allosteric Modulator of GluN2B with Potential Utility in Major Depressive Disorder.
Open access · greenAbstract read
In one paragraph
Article in ACS medicinal chemistry letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 17 citations in OpenAlex.
- Polarity-determined triple partition of dual binding pockets unlocks mechanistic insights and a novel antagonist design of NMDA receptors: a combined MD/DFT study.RSC advances · 2026Article
- Demystifying the Antidepressant Mechanism of Action of Stinels, a Novel Class of Neuroplastogens: Positive Allosteric Modulators of the NMDA Receptor.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Therapeutic potential of N-methyl-D-aspartate receptor modulators in psychiatry.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.Pharmacological reviews · 2021Review
- A GlutamateThe Journal of pharmacology and experimental therapeutics · 2021Article
- Ifenprodil rapidly ameliorates depressive-like behaviors, activates mTOR signaling and modulates proinflammatory cytokines in the hippocampus of CUMS rats.Psychopharmacology · 2020Article
- Synthesis and Preliminary Evaluations of a Triazole-Cored Antagonist as a PET Imaging Probe ([ACS chemical neuroscience · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
48 authors at 2 institutions in 2 countries.
Lawrence R MarcinBristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, Connecticut 06492, United States.
Jayakumar WarrierBiocon Bristol-Myers Squibb Research Center, Bangalore, India.
Srinivasan ThangathirupathyBiocon Bristol-Myers Squibb Research Center, Bangalore, India.
Jianliang ShiBristol-Myers Squibb Research and Development, 3551 Lawrenceville Road, Princeton, New Jersey 08648, United States.
George N KarageorgeBristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, Connecticut 06492, United States.
Bradley C PearceBristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, Connecticut 06492, United States.
Alicia NgBristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, Connecticut 06492, United States.
Hyunsoo ParkBristol-Myers Squibb Research and Development, 3551 Lawrenceville Road, Princeton, New Jersey 08648, United States.
James KempsonBristol-Myers Squibb Research and Development, 3551 Lawrenceville Road, Princeton, New Jersey 08648, United States.
Jianqing LiBristol-Myers Squibb Research and Development, 3551 Lawrenceville Road, Princeton, New Jersey 08648, United States.
Huiping ZhangBristol-Myers Squibb Research and Development, 3551 Lawrenceville Road, Princeton, New Jersey 08648, United States.
Arvind MathurBristol-Myers Squibb Research and Development, 3551 Lawrenceville Road, Princeton, New Jersey 08648, United States.
Aliphedi B ReddyBiocon Bristol-Myers Squibb Research Center, Bangalore, India.
G NagarajuBiocon Bristol-Myers Squibb Research Center, Bangalore, India.
Gopikishan TonukunuruBiocon Bristol-Myers Squibb Research Center, Bangalore, India.
Grandhi V R K M GuptaBiocon Bristol-Myers Squibb Research Center, Bangalore, India.
Manjunatha KambleBiocon Bristol-Myers Squibb Research Center, Bangalore, India.
Raju MannooriBiocon Bristol-Myers Squibb Research Center, Bangalore, India.
Srinivas CherukuBiocon Bristol-Myers Squibb Research Center, Bangalore, India.
Srinivas JogiBiocon Bristol-Myers Squibb Research Center, Bangalore, India.
Jyoti GuliaBiocon Bristol-Myers Squibb Research Center, Bangalore, India.
Tanmaya BastiaBiocon Bristol-Myers Squibb Research Center, Bangalore, India.
Charulatha SanmathiBiocon Bristol-Myers Squibb Research Center, Bangalore, India.
Jayant AherBiocon Bristol-Myers Squibb Research Center, Bangalore, India.
Rajareddy KallemBiocon Bristol-Myers Squibb Research Center, Bangalore, India.
Bettadapura N SrikumarBiocon Bristol-Myers Squibb Research Center, Bangalore, India.
Kumar Kuchibhotla VijayaBiocon Bristol-Myers Squibb Research Center, Bangalore, India.
Pattipati S NaiduBiocon Bristol-Myers Squibb Research Center, Bangalore, India.
Mahesh PaschapurBiocon Bristol-Myers Squibb Research Center, Bangalore, India.
Narasimharaju KalidindiBiocon Bristol-Myers Squibb Research Center, Bangalore, India.
Reeba VikramadithyanBiocon Bristol-Myers Squibb Research Center, Bangalore, India.
Manjunath RamaraoBiocon Bristol-Myers Squibb Research Center, Bangalore, India.
Rex DentonBristol-Myers Squibb Research and Development, 3551 Lawrenceville Road, Princeton, New Jersey 08648, United States.
Thaddeus MolskiBristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, Connecticut 06492, United States.
Eric ShieldsBristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, Connecticut 06492, United States.
Murali SubramanianBiocon Bristol-Myers Squibb Research Center, Bangalore, India.
Xiaoliang ZhuoBristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, Connecticut 06492, United States.
Michelle NophskerBristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, Connecticut 06492, United States.
Jean SimmermacherBristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, Connecticut 06492, United States.
Michael SinzBiocon Bristol-Myers Squibb Research Center, Bangalore, India.
Charlie AlbrightBristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, Connecticut 06492, United States.
Linda J BristowBristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, Connecticut 06492, United States.
Imadul IslamBiocon Bristol-Myers Squibb Research Center, Bangalore, India.
Joanne J BronsonBristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, Connecticut 06492, United States.
Richard E OlsonBristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, Connecticut 06492, United States.
Dalton KingBristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, Connecticut 06492, United States.
Lorin A ThompsonBristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, Connecticut 06492, United States.
John E MacorBristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, Connecticut 06492, United States.
Bristol-Myers Squibb (India) · INBristol-Myers Squibb (United States) · US
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is a significant unmet medical need for more efficacious and rapidly acting antidepressants. Toward this end, negative allosteric modulators of the
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.