Evidence map›Paper›PMID 29795686›Full record

ArticlePloS one2018

β2-microglobulin induces depressive- and anxiety-like behaviors in rat.

Ping Zhang, Dan Zeng, Yi-Li Yi, Yi-Yun Tang, Wei Zou, Xue-Feng Yang, Chun-Yan Wang, Xiao-Qing Tang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Ping ZhangDepartment of Neurology, Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan, China.
Dan ZengDepartment of Neurology, Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan, China.
Yi-Li YiDepartment of Neurology, Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan, China.
Yi-Yun TangInstitute of Neuroscience, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, Hunan, China.
Wei ZouDepartment of Neurology, Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan, China.
Xue-Feng YangDepartment of Gastroenterology, Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan, China.
Chun-Yan WangInstitute of Neuroscience, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, Hunan, China.
Xiao-Qing TangInstitute of Neuroscience, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, Hunan, China.ORCID 0000-0002-3518-9275
University of South China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

β2-microglobulin (B2M), the light chain of major histocompatibility complex class I (MHC I) molecules, has been found to impair hippocampal neurogenesis. Based on the crucial role of hippocampal neurogenesis disturbance in the process of depression and anxiety, the aim of the present study is to investigate whether B2M leads to depressive- and anxiety-like behaviors. We found that 6 days after intracerebroventricular injection with B2M (0.3 μg), the immobility times of rats in the tail suspension test and the forced swimming test were increased, the swimming and climbing time in the forced swimming test was decreased, and the latency to feed in the novelty-suppressed feeding test was increased, indicating that B2M induces depressive-like behaviors. In addition, in the elevated plus maze test, B2M-treated rats displayed obvious decline in the number of entries into and the proportion of time spent in the open arm, while the number of total arm entries was no change, which indicated that B2M induces anxiety-like behaviors. Our present findings suggest that target B2M might represent a novel approach for treatment of depression and anxiety.

Indexed as

Behavior, AnimalDisease Models, AnimalAnimalsAnxiety Disordersbeta 2-MicroglobulinDepressive DisorderMaleRatsRats, Sprague-Dawleybeta 2-Microglobulin

Identifiers

PMID29795686
PMCPMC5968416
OpenAlexW2804386707

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.