ArticlePloS one2018
Uncovering production of specialized metabolites by Streptomyces argillaceus: Activation of cryptic biosynthesis gene clusters using nutritional and genetic approaches.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 50 citations in OpenAlex.
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- Functional Assessment of Orphan Proteins in theMicroorganisms · 2026Article
- Comparative genomics reveals hidden biosynthetic diversity inFrontiers in microbiology · 2026Article
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- Discovery of Streptomyces marinisediminis sp. nov., a new thiolutin producing actinomycete isolated from Thai marine sediment.Scientific reports · 2025Article
- Biosynthetic Pathway of psi, psi-Carotene fromFrontiers in microbiology · 2025Article
- Genomic and physiological characterization of Kitasatospora sp. nov., an actinobacterium with potential for biotechnological application isolated from Cerrado soil.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Transcriptional regulators of secondary metabolite biosynthesis in Streptomyces.World journal of microbiology & biotechnology · 2024Review
- Discovery of thiazostatin D/E using UPLC-HR-MS2-based metabolomics and σ-factor engineering ofFrontiers in bioengineering and biotechnology · 2024Article
- The Pangenome of Gram-Negative Environmental Bacteria Hides a Promising Biotechnological Potential.Microorganisms · 2023Article
- Uncovering the Cryptic Gene ClusterInternational journal of molecular sciences · 2023Article
- Elicitation for activation of the actinomycete genome's cryptic secondary metabolite gene clusters.RSC advances · 2023Review
- Whole-genome sequencing-based characterization ofAccess microbiology · 2023Article
- Two-Component Systems ofInternational journal of molecular sciences · 2022Review
- Biosynthesis of Largimycins inACS chemical biology · 2022Article
- Characterization of Microbial Diversity in Decayed Wood from a Spanish Forest: An Environmental Source of Industrially Relevant Microorganisms.Microorganisms · 2022Article
- Grapevine Xylem Sap Is a Potent Elicitor of Antibiotic Production inAntibiotics (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sequencing of Streptomyces genomes has revealed they harbor a high number of biosynthesis gene cluster (BGC), which uncovered their enormous potentiality to encode specialized metabolites. However, these metabolites are not usually produced under standard laboratory conditions. In this manuscript we report the activation of BGCs for antimycins, carotenoids, germicidins and desferrioxamine compounds in Streptomyces argillaceus, and the identification of the encoded compounds. This was achieved by following different strategies, including changing the growth conditions, heterologous expression of the cluster and inactivating the adpAa or overexpressing the abrC3 global regulatory genes. In addition, three new carotenoid compounds have been identified.
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