ArticlePloS one2018
Peak oxygen uptake (VO2peak) across childhood, adolescence and young adulthood in Barth syndrome: Data from cross-sectional and longitudinal studies.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Trial
- The influence of a 16-week exercise program, APOE status, and age on executive function task performance: A randomized trial.Experimental gerontology · 2021Trial
- Few Structural Brain Changes Associated With Moderate-Intensity Interval Training and Low-Intensity Continuous Training in a Randomized Trial of Fitness and Older Adults.Journal of aging and physical activity · 2021Trial
- The role of bioactive lipids and eicosanoid metabolites in acute exercise in adults: Insights into human cardiorespiratory fitness.Physiological reports · 2025Article
- Effects of 8-weeks Surf Skateboard training on physical fitness in young people.Sports medicine and health science · 2025Article
- Cardiac Transplantation Does Not Improve Exercise Tolerance, Muscle Mass, or Substrate Metabolism in Barth Syndrome.JIMD reports · 2025Article
- One episode of low intensity aerobic exercise prior to systemic AAV9 administration augments transgene delivery to the heart and skeletal muscle.Journal of translational medicine · 2023Article
- The Comparison of High-Intensity Interval Training Versus Moderate-Intensity Continuous Training after Coronary Artery Bypass Graft: A Systematic Review of Recent Studies.Journal of cardiovascular development and disease · 2022Review
- Lifestyle Matters: Effects of Habitual Physical Activity on Driving Skills in Older Age.Brain sciences · 2022Article
- Associations Between Age and Resting State Connectivity Are Partially Dependent Upon Cardiovascular Fitness.Frontiers in aging neuroscience · 2022Article
- Cardiopulmonary Capacity in Overweight and Obese Children and Adolescents: A Cross-Sectional Study.Frontiers in physiology · 2021Article
- Relation between Exercise Performance and Blood Storage Condition and Storage Time in Autologous Blood Doping.Biology · 2020Review
- Effects of 24-Week Exergame Intervention on the Gray Matter Volume of Different Brain Structures in Women with Fibromyalgia: A Single-Blind, Randomized Controlled Trial.Journal of clinical medicine · 2020Article
- Increased mtDNA Abundance and Improved Function in Human Barth Syndrome Patient Fibroblasts Following AAV-International journal of molecular sciences · 2019Article
- Functional exercise capacity, strength, balance and motion reaction time in Barth syndrome.Orphanet journal of rare diseases · 2019Article
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
Barth syndrome (BTHS) is an ultra-rare, X-linked recessive disorder characterized by cardio-skeletal myopathy, exercise intolerance, and growth delay. Oxygen uptake during peak exercise (VO2peak) has been shown to be severely limited in individuals with BTHS however; the trajectory of VO2peak from childhood to young adulthood is unknown. The objective of this study was to describe VO2peak from childhood through young adulthood in BTHS. METHODS AND MATERIALS: VO2peak over time was presented through cross-sectional (n = 33 participants) and a longitudinal analyses (n = 12 participants). Retrospective data were obtained through maximal exercise testing on a cycle ergometer from individuals with BTHS who were or are currently enrolled in a research study during July 2006-September 2017. Participants included in the cross-sectional analysis were divided into 3 groups for analysis: 1) children (n = 13), 2) adolescents (n = 8), and 3) young adults (n = 12). Participants in the longitudinal analysis had at least two exercise tests over a span of 2-9 years.
resultsVO2peak relative to body weight (ml/kgBW/min), fat-free mass (FFM) and by percent of predicted VO2peak obtained were not significantly different between children, adolescents and young adults. VO2peak did not longitudinally change over a mean time of ~5 years in late adolescent and young adult participants with repeated tests. A model including both cardiac and skeletal muscle variables best predicted VO2peak.
conclusionsIn conclusion, VO2peak relative to body weight and fat-free mass demonstrates short- and long-term stability from childhood to young adulthood in BTHS with some variability among individuals.
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