ArticlePloS one2018
A method for age-matched OCT angiography deviation mapping in the assessment of disease- related changes to the radial peripapillary capillaries.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- Aging affects retinal oxygen and blood flow metrics in mice.Experimental eye research · 2025Article
- Vascular density normative data of radial peripapillary capillary plexus in healthy Caucasian subjects.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Article
- Assessing the Sensitivity of OCT-A Retinal Vasculature Metrics.Translational vision science & technology · 2023Article
- Optic disc and peripapillary vessel density measured with optical coherence tomography angiography and its associations in Chinese adults: a large population-based study.The British journal of ophthalmology · 2022Article
- Age-related assessment of foveal avascular zone and surrounding capillary networks with swept source optical coherence tomography angiography in healthy eyes.Eye (London, England) · 2022Observational
- Thyroid-Associated Peripapillary Vascular Remodelling - A Novel Area for Research? [Letter].Clinical ophthalmology (Auckland, N.Z.) · 2022Article
- A Pilot Study of Subclinical Non-Capillary Peripapillary Perfusion Changes in Thyroid-Related Orbitopathy Detected Using Optical Coherence Tomography Angiography.Clinical ophthalmology (Auckland, N.Z.) · 2022Article
- Combined wide-field optical coherence tomography angiography density map for high myopic glaucoma detection.Scientific reports · 2021Observational
- Retinal alterations in patients with Lafora disease.American journal of ophthalmology case reports · 2021Article
- Optical coherence tomography angiography-derived flow density: a review of the influencing factors.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2020Review
- Foveal avascular zone morphology and parafoveal capillary perfusion in sickle cell retinopathy.The British journal of ophthalmology · 2020Article
- Age-related changes in macular vessels and their perfusion densities on optical coherence tomography angiography.Indian journal of ophthalmology · 2020Article
- The vascular densities of the macula and optic disc in normal eyes from children by optical coherence tomography angiography.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2020Article
- Interocular asymmetry of foveal avascular zone morphology and parafoveal capillary density in sickle cell retinopathy.PloS one · 2020Article
- Systemic Determinants of Peripapillary Vessel Density in Healthy African Americans: The African American Eye Disease Study.American journal of ophthalmology · 2019Article
- Ocular Determinants of Peripapillary Vessel Density in Healthy African Americans: The African American Eye Disease Study.Investigative ophthalmology & visual science · 2019Article
- Novel Development of Parafoveal Capillary Density Deviation Mapping using an Age-Group and Eccentricity Matched Normative OCT Angiography Database.Translational vision science & technology · 2019Article
- The Utility of Frame Averaging for Automated Algorithms in Analyzing Retinal Vascular Biomarkers in AngioVue OCTA.Translational vision science & technology · 2019Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
purposeTo present a method for age-matched deviation mapping in the assessment of disease-related changes to the radial peripapillary capillaries (RPCs).
methodsWe reviewed 4.5x4.5mm en face peripapillary OCT-A scans of 133 healthy control eyes (133 subjects, mean 41.5 yrs, range 11-82 yrs) and 4 eyes with distinct retinal pathologies, obtained using spectral-domain optical coherence tomography angiography. Statistical analysis was performed to evaluate the impact of age on RPC perfusion densities. RPC density group mean and standard deviation maps were generated for each decade of life. Deviation maps were created for the diseased eyes based on these maps. Large peripapillary vessel (LPV; noncapillary vessel) perfusion density was also studied for impact of age.
resultsAverage healthy RPC density was 42.5±1.47%. ANOVA and pairwise Tukey-Kramer tests showed that RPC density in the ≥60yr group was significantly lower compared to RPC density in all younger decades of life (p<0.01). Average healthy LPV density was 21.5±3.07%. Linear regression models indicated that LPV density decreased with age, however ANOVA and pairwise Tukey-Kramer tests did not reach statistical significance. Deviation mapping enabled us to quantitatively and visually elucidate the significance of RPC density changes in disease.
conclusionsIt is important to consider changes that occur with aging when analyzing RPC and LPV density changes in disease. RPC density, coupled with age-matched deviation mapping techniques, represents a potentially clinically useful method in detecting changes to peripapillary perfusion in disease.
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